Preview

Title

Advanced search

Gastric MALT Lymphoma in a Patient with Chronic Gastritis Associated with Helicobacter pylori

https://doi.org/10.31550/1727-2378-2022-21-6-45-48

Abstract

Objective of the Paper: To analyze the development and course of gastric MALT-lymphoma in a patient with chronic gastritis associated with Helicobacter pylori.
Key points. Regression of gastric MALT-lymphoma, diagnosed in a 68-year-old patient at stage IE2, was achieved by a combination of 6 courses of immunochemotherapy according to the R-B protocol (rituximab and bendamustine) and H. pylori eradication.
Conclusion. Clinical observation demonstrates the etiological relationship between gastric MALT-lymphoma and the H. pylori infection in the upper digestive tract, as well as the positive effect of immunochemotherapy and persistent eradication therapy, which contributed to the regression of gastric MALT-lymphoma itself and affected intra-abdominal lymph nodes.

About the Authors

G. S. Dzhulay
Tver State Medical University
Russian Federation

4 Sovietskaya Str., Tver, 170100



T. E. Dzhulay
Tver State Medical University
Russian Federation

4 Sovietskaya Str., Tver, 170100



References

1. Bakulin I.G., Bakulina N.V., Vorobyov S.L., Popova E.A. et al. MALT lymphoma and erosive and ulcerative lesions of the stomach: modern diagnostic approaches and own clinical observation. Oncohematology. 2019; 14(3): 23–37. (in Russian). DOI: 10.17650/1818-8346-2019-14-3-23-37

2. Mayev I.V., Andreyev D.N., Kucheryavy Yu.A. MALT-lymphoma of the stomach: state-of-the-art. Clinical Perspectives of Gastroenterology, Hepatology. 2015; 6: 3–9. (in Russian)

3. Selezneva E.Ya., Shcherbakova N.A., Embutnieks Yu.V., Bystrovskaya E.V. et al. Diagnosing MALT gastric lymphoma in gastroenterologist’s practice, a clinical observation. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2021; 31(3): 60–7. (in Russian). DOI: 10.22416/1382-4376-2021-31-3-60-67

4. Korzheva I.Yu., Chernekhovskaya N.E., Razzhivina A.A., Hayrapetyan N.A. et al. Clinical and endoscopic diagnosis of MALT-lymphoma of the duodenum. Experimental and Clinical Gastroenterology. 2021; 189(5): 82–5. (in Russian). DOI: 10.31146/1682-8658-ecg-189-5-82-85

5. Filip P.V., Cuciureanu D., Laura Sorina Diaconu L.S., Vladareanu A.M. et al. MALT lymphoma: epidemiology, clinical diagnosis and treatment. Med. Life. 2018; 11(3): 187–93. DOI: 10.25122/jml-2018-0035

6. Raderer M., Kiesewetter B. What you always wanted to know about gastric MALT-lymphoma: a focus on recent developments. Ther. Adv. Med. Oncol. 2021; 13: 17588359211033825. DOI: 10.1177/17588359211033825

7. Zenzri Y., Charfi L., Sahraoui G., Yahyaoui Y. et al. Gastric mucosaassociated lymphoid tissue (MALT) lymphoma: clinicopathological study and treatment outcome in 50 patients. Pan. Afr. Med. J. 2020; 37: 372. DOI: 10.11604/pamj.2020.37.372.27094

8. Matysiak-Budnik T., Jamet P., Ruskoné-Fourmestraux A., de Mascarel A. et al. Gastric MALT lymphoma in a population-based study in France: clinical features, treatments and survival. Aliment. Pharmacol. Ther. 2019; 50(6): 654–63. DOI: 10.1111/apt.15409

9. Kostalanova Yu.V., Davydkin I.L., Koroleva I.A., Osadchuk A.M. et al. MALT-lymphoma of the stomach and chronic H. pylori-associated gastritis: clinical, endoscopic, morphological and immunohistochemical comparison. Siberian Scientific Medical Journal. 2015; 35(1): 98–106. (in Russian)

10. Thieblemont C., Zucca E. Clinical aspects and therapy of gastrointestinal MALT lymphoma. Best Pract. Res. Clin. Haematol. 2017; 30(1–2): 109–17. DOI: 10.1016/j.beha.2017.01.002

11. Du M.-Q. MALT lymphoma: genetic abnormalities, immunological stimulation and molecular mechanism. Best Pract. Res. Clin. Haematol. 2017; 30(1–2): 13–23. DOI: 10.1016/j.beha.2016.09.002

12. Rodríguez-Sevilla J.J., Antonio Salar A. Recent advances in the genetic of MALT lymphomas. Cancers (Basel). 2021; 14(1): 176. DOI: 10.3390/cancers14010176

13. Izrailov R.E., Pomortsev B.A., Semenov N.E., Pivnik A.V. A complicated form of extranodal gastric lymphoma. Modern possibilities of surgical treatment. Rare clinical case. Endoscopic Surgery. 2020; 26(1): 35–9. (in Russian). DOI: 10.17116/endoscop20202601135

14. Tian Y., Sun K.-Y., Meng T.-Q., Ye Z. et al. Gut microbiota may not be fully restored in recovered COVID-19 patients after 3-month recovery. Front. Nutr. 2021; 8: 638825. DOI: 10.3389/fnut.2021.638825

15. Villapol S. Gastrointestinal symptoms associated with COVID-19: impact on the gut microbiome. Transl. Res. 2020; 226: 57–69. DOI: 10.1016/j.trsl.2020.08.004


Review

For citations:


Dzhulay G.S., Dzhulay T.E. Gastric MALT Lymphoma in a Patient with Chronic Gastritis Associated with Helicobacter pylori. Title. 2022;21(6):45-48. (In Russ.) https://doi.org/10.31550/1727-2378-2022-21-6-45-48

Views: 13


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1727-2378 (Print)
ISSN 2713-2994 (Online)