Clinical and Neurochemical Characteristics of Mentally Ill Patients with Aggressive Misconduct
https://doi.org/10.31550/1727-2378-2023-22-6-15-20
Abstract
Aim: To analyse clinical, biochemical and social characteristics of patients with severe mental disorders and aggressive behaviour.
Design: observational cross-sectional study.
Materials and methods. We examined 110 patients of 18–60 years of age with severe mental disorders and persistent aggressive behaviour who committed acts of violence. For examination, we used clinical psychopathologic, psychometric, laboratory, mathematical and statistical methods.
Results. The subjects had disturbed upbringing with signs of violence, undereducation, family and occupational maladaptation, conflict relations with people around them, financial insecurity. Clinically, they demonstrated marked behavioural disorders with explosive episodes associated with hetero-aggressive trends, with decreased intellectual and volitional control and lack of compliance. There were statistically significant (p < 0.05) differences in biological parameters of a majority of patients vs. reference values and correlation between psychometric and biochemical data.
Conclusion. The results contribute to the identification of predictors of socially dangerous violent behaviour in persons with severe mental disorders.
About the Authors
O. A. Makushkina
V.P. Serbsky National Medical Research Center for Psychiatry and Narcology
Russian Federation
Russian Federation
23 Kropotkinsky Pereulok, Moscow, 119992
O. I. Gurina
V.P. Serbsky National Medical Research Center for Psychiatry and Narcology
Russian Federation
Russian Federation
23 Kropotkinsky Pereulok, Moscow, 119992
A. V. Frolova
V.P. Serbsky National Medical Research Center for Psychiatry and Narcology
Russian Federation
Russian Federation
23 Kropotkinsky Pereulok, Moscow, 119992
V. A. Golenkova
V.P. Serbsky National Medical Research Center for Psychiatry and Narcology
Russian Federation
Russian Federation
23 Kropotkinsky Pereulok, Moscow, 119992
References
1. Parshakova A.N., Tsepova Y.S., Trutneva N.V., Yatmanov V.G. Manifestations of aggressive behavior in patients with schizophrenia and their treatment. International Student Scientific Bulletin. 2019;1:26–32. (in Russian). URL: https://eduherald.ru/ru/article/view?id=1954 (дата обращения — 12.02.2023).
2. Golenkov A.V. Clinical and social characteristics of patients with schizophrenia with socially dangerous behavior. In: Makushkin E.V., Fastovtsev G.A. (ed.). Materials of the Scientific and Practical Conference (with international participants). Moscow, 18–20 September 2018. Materials of the scientific-practical conference with international participation. M.; 2018: 40–2. (in Russian).
3. Elbogen E.B., Johnson S.C. The intricate link between violence and mental disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch. Gen. Psychiatry. 2009;66(2):152– 61. DOI: 10.1001/archgenpsychiatry.2008.537
4. Whiting D., Lichtenstein P., Fazel S. Violence and mental disorders: a structured review of associations by individual diagnoses, risk factors, and risk assessment. Lancet Psychiatry. 2021;8(2):150–61. DOI: 10.1016/S2215-0366(20)30262-5
5. Makushkina O.A., Frolova A.V., Burygina L.A., Golenkova V.A. Clinical and social factors as a predictor of aggressive behavior in people with severe mental disorders. Siberian Bulletin of Psychiatry and Narcology. 2022;1(114):15–26. (in Russian). DOI: 10.26617/1810-3111-2022-1(114)-15-26" \t "_blank
6. Ten Have M., de Graaf R., van Weeghel J., van Dorsselaer S. The association between common mental disorders and violence: to what extent is it influenced by prior victimization, negative life events and low levels of social support? Psychol. Med. 2014;44(7):1485–98. DOI: 10.1017/S0033291713002262
7. Watts D., de Azevedo Cardoso T., Librenza-Garcia D., Ballester P. et al. Predicting criminal and violent outcomes in psychiatry: a meta-analysis of diagnostic accuracy. Transl. Psychiatry. 2022;12(1):470. DOI: 10.1038/s41398-022-02214-3
8. Ling S., Umbach R., Raine A. Biological explanations of criminal behavior. Psychol. Crime Law. 2019;25(6):626–40. DOI: 10.1080/1068316X.2019.1572753
9. Toshchakova V.A., Vyalova N.M., Boyko A.S., Gusev S.I. et al. Cortisol and adrenocorticotropic hormone level in male criminals. Basic Research. 2013;12(1):81–4. (in Russian). URL: https://fundamental-research.ru/ru/article/view?id=33040 (дата обращения — 12.02.2023).
10. Makushkina O.A., Gurina O.I., Golenkova V.A. Biological basis of aggressive behavior. Neurology, Neuropsychiatry, Psychosomatics. 2022;14(1):76–81. (in Russian). DOI: 10.14412/2074- 2711-2022-1-76-81
11. Trifu S.C., Tudor A., Radulescu I. Aggressive behavior in psychiatric patients in relation to hormonal imbalance (Review). Exp. Ther. Med. 2020;20(4):3483–87. DOI: 10.3892/etm.2020.8974
12. Sturmey P. Biological evolution of violence and aggression. II: Brains, neurotransmitters, and hormones. In: Violence and Aggression. Advances in Preventing and Treating Violence and Aggression. Switzerland: Springer, Cham; 2022: 121–43. DOI: 10.1007/978-3-031-04386-4_5
13. Nichkova M.I., Huisman H., Wynveen P.M., Marc D.T. et al. Evaluation of a novel ELISA for serotonin: urinary serotonin as a potential biomarker for depression. Anal. Bioanal. Chem. 2012;402(4):1593–600. DOI: 10.1007/s00216-011-5583-1
14. McKernan L.C., Walsh C.G., Reynolds W.S., Crofford L.J. et al. Psychosocial co-morbidities in Interstitial Cystitis/Bladder Pain syndrome (IC/BPS): A systematic review. Neurourol. Urodyn. 2018;37(3):926-41. DOI: 10.1002/nau.23421
15. Kogan B.M., Vinnikova I.N., Guzenko O.V., Drozdov A.Z. et al. A comparative study of the excretion of catecholamines in patients with depressive manifestations associated with schizotypal and psychogenis disorders. Russian Journal of Psychiatry. 2011;4:73–8. (in Russian)].
16. Chekhonin V.P., Baklaushev V.P., Kogan B.M., Savchenko E.A. et al. Catecholamines and their metabolites in the brain and urine of rats with experimental Parkinson’s disease. Bull. Exp. Biol. Med. 2000;130(8):805–9. DOI: 10.1007/BF02766101
17. Jayamohananan H., Kumar M.K.M., Aneesh T.P. 5-HIAA as a potential biological marker for neurological and psychiatric disorders. Adv. Pharm. Bull. 2019;9(3):374–81. DOI: 10.15171/apb.2019.044
18. Kogan B.M., Nechaev N.V. Sensitive and fast method of simultaneous detection of dopamine, norepinephrine, serotonin and 5-oxyndroacetic acid in one sample. Laboratory Case. 1979;5:301–3. (in Russian).
19. Makushkina O.A. Methodology for structured risk assessment of dangerous behavior of persons with mental disorders (SORAP). M.: NMITs PN im.V.P. Serbskogo, 2020. 37 p. (in Russian).
20. Hagenbeek F.A., Kluft C., Hankemeier T., Bartels M. et al. Discovery of biochemical biomarkers for aggression: A role for metabolomics in psychiatry. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 2016;171(5):719–32. DOI: 10.1002/ajmg.b.32435
21. Geniole S.N., Bird B.M., McVittie J.S., Purcell R.B. et al. Is testosterone linked to human aggression? A meta-analytic examination of the relationship between baseline, dynamic, and manipulated testosterone on human aggression. Horm. Behav. 2020;123:104644. Epub. 2019 Dec. 28. DOI: 10.1016/j.yhbeh.2019.104644
22. Manigault A.W., Zoccola P.M., Hamilton K., Wymbs B.T. Testosterone to cortisol ratio and aggression toward one's partner: Evidence for moderation by provocation. Psychoneuroendocrinology. 2019;103:130– 6. DOI: 10.1016/j.psyneuen.2019.01.018
Review
For citations:
Makushkina O.A., Gurina O.I., Frolova A.V., Golenkova V.A. Clinical and Neurochemical Characteristics of Mentally Ill Patients with Aggressive Misconduct. Title. 2023;22(6):15-20. (In Russ.) https://doi.org/10.31550/1727-2378-2023-22-6-15-20
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