Clinical and Anamnestic Risk Factors of Preeclampsia as Complications of Gestational Diabetes Mellitus
https://doi.org/10.31550/1727-2378-2024-23-2-7-11
Abstract
Aim. To identify the clinical and anamnestic risk factors of preeclampsia (PE) in gestational diabetes mellitus (GDM).
Design. Open-label observational prospective study.
Materials and methods. The study enrolled 204 pregnant women with GDM, 70 of which had their pregnancy complicated with PE (study group) and 134 patients did not have PE (controls). In the study group, clinical and anamnestic risk factors were searched for by tracing data from primary medical records. The age of participants was 21 to 46 years old. Extragenital conditions were studied as possible risk factors of PE in GDM.
Results. It has been established that GDM with PE was more likely to be associated with chronic arterial hypertension (CAH) (χ2 = 7.72, р = 0.006, odds ratio (OR) = 8.52, 95% confidence interval (CI): 1.76–41.29); a history of respiratory diseases — severe sore throat (χ2 = 6.2, р = 0.01, OR = 3.98, 95% CI: 1.40–11.27), chronic tonsillitis (χ2 = 12.84, р < 0.001, OR = 4.81, 95% CI: 2.03–11.40), acute bronchitis (χ2 = 6.0, р = 0.02, OR = 7.33, 95% CI: 1.48–36.32) than GDM without PE.
Conclusion. Clinical and anamnestic risk factors of PE in women with GDM are CAH, a history of respiratory diseases (acute bronchitis, severe sore throat, chronic tonsillitis).
About the Authors
V. E. Radzinsky
Peoples' Friendship University of Russia named after Patrice Lumumba
Russian Federation
Russian Federation
6, Miklukho-Maklay Str., Moscow, 117198.
V. M. Grabovskiy
Moscow City Clinical Hospital 52
Russian Federation
Russian Federation
3, Pekhotnaya Str., Moscow, 123182.
А. А. Epishkina-Minina
Peoples' Friendship University of Russia named after Patrice Lumumba; Moscow City Clinical Hospital 31 named after academician G.M. Savelyeva;
Russian Federation
Russian Federation
6, Miklukho-Maklay Str., Moscow, 117198;
42, Lobachevsky Str., Moscow, 119415.
M. B. Khamoshina
Peoples' Friendship University of Russia named after Patrice Lumumba
Russian Federation
Russian Federation
6, Miklukho-Maklay Str., Moscow, 117198.
А. А. Orazmuradov
Peoples' Friendship University of Russia named after Patrice Lumumba
Russian Federation
Russian Federation
6, Miklukho-Maklay Str., Moscow, 117198.
References
1. Liu Y., Li D.Y., Bolatai A., Wu N. Progress in research on biomarkers of gestational diabetes mellitus and preeclampsia. Diabetes Metab. Syndr. Obes. 2023;16:3807–15. DOI: 10.2147/DMSO.S433179
2. Awamleh Z., Gloor G.B., Han V.K.M. Placental microRNAs in pregnancies with early onset intrauterine growth restriction and preeclampsia: potential impact on gene expression and pathophysiology. BMC Med. Genomics. 2019;12(1):91. DOI: 10.1186/s12920-019-0548-x
3. Kahimakazi I., Tornes Y.F., Tibaijuka L., Kanyesigye H. et al. Prevalence of gestational diabetes mellitus and associated factors among women receiving antenatal care at a tertiary hospital in South-Western Uganda. Pan Afr. Med. J. 2023;46:50. DOI: 10.11604/pamj.2023.46.50.38355
4. Gyasi-Antwi P., Walker L., Moody C., Okyere S. et al. Global prevalence of gestational diabetes mellitus: a systematic review and metaanalysis. New Am. J. Med. 2020;1(3):1–10.
5. Yang Y., Wu N. Gestational diabetes mellitus and preeclampsia: correlation and influencing factors. Front. Cardiovasc. Med. 2022;9:831297. DOI: 10.3389/fcvm.2022.831297
6. Епишкина-Минина А.А., Хамошина М.Б., Оразмурадов А.А., Лебедева М.Г. и др. Гестационный сахарный диабет: прогнозирование у женщин с анемическим синдромом. Акушерство и гинекология: новости мнения, обучение. 2020;8(3):47–54. [Epishkina-Minina A.A., Khamoshina M.B., Orazmuradov A.A., Lebedeva M.G. et al. Gestational diabetes mellitus: prediction in pregnant women with anemic syndrome. Obstetrics and Gynecology: News, Opinions, Training. 2020;8(3):47–54. (in Russian).] DOI: 10.24411/2303-9698-2020-13006
7. Ferrari N., Joisten C. Impact of physical activity on course and outcome of pregnancy from pre- to postnatal. Eur. J. Clin. Nutr. 2021;75(12):1698–709. DOI: 10.1038/s41430-021-00904-7
8. Jakobsen C., Larsen J.B., Fuglsang J., Hvas A.M. Platelet function in preeclampsia — a systematic review and meta-analysis. Platelets. 2019;30(5):549–62. DOI: 10.1080/09537104.2019.1595561
9. Li Y., Ren X., He L., Li J. et al. Maternal age and the risk of gestational diabetes mellitus: a systematic review and metaanalysis of over 120 million participants. Diabetes Res. Clin. Pract. 2020;162:108044. DOI: 10.1016/j.diabres.2020.108044
10. Swift E.M., Gunnarsdottir J., Zoega H., Bjarnadottir R.I. et al. Trends in labor induction indications: a 20-year population-based study. Acta Obstet. Gynecol. Scand. 2022;101(12):1422–30. DOI: 10.1111/aogs.14447
11. Durlach V., Vergès B., Al-Salameh A., Bahougne T. et al. Smoking and diabetes interplay: a comprehensive review and joint statement. Diabetes Metab. 2022;48(6):101370. DOI: 10.1016/j.diabet.2022.101370
12. Deng L., Ning B., Yang H. Association between gestational diabetes mellitus and adverse obstetric outcomes among women with advanced maternal age: a retrospective cohort study. Medicine (Baltimore). 2022;101(40):e30588. DOI: 10.1097/MD.0000000000030588
13. Аникеев А.С., Старцева Н.М., Грабовский В.М., Ордиянц И.М. и др. Особенности метаболизма у женщин с преэклампсией, сочетающейся с гестационным сахарным диабетом. Доктор.Ру. 2023;22(1):62–7. [Anikeev A.S., Startseva N.M., Grabovsky V.M., Ordiyants I.M. et al. Features of metabolism in women with preeclampsia combined with gestational diabetes mellitus. Doctor.Ru. 2023;22(1):62–7. (in Russian).] DOI: 10.31550/17272378-2023-22-1-62-67
Review
For citations:
Radzinsky V.E., Grabovskiy V.M., Epishkina-Minina А.А., Khamoshina M.B., Orazmuradov А.А. Clinical and Anamnestic Risk Factors of Preeclampsia as Complications of Gestational Diabetes Mellitus. Title. 2024;23(2):7-11. (In Russ.) https://doi.org/10.31550/1727-2378-2024-23-2-7-11
Views:
11
Email this article 