Patient Blood Management Conception in the Practice of an Obstetrician-Gynecologist: What to Pay Attention to?
https://doi.org/10.31550/1727-2378-2024-23-5-56-61
Abstract
Aim. To present literature and own data on the implementation of the concept of patient blood management (PBM) in obstetrics and gynecology.
Key points. PBM involves “the timely, interdisciplinary application of evidence-based, multimodal medical and surgical concepts aimed at screening, diagnosing and appropriately treating anemia, minimizing surgical, procedural, iatrogenic blood loss, and managing coagulopathy bleeding to improve health outcomes through patient-centered care”. As part of the PBM, it is important for the obstetriciangynecologist to first screen for iron deficiency (ID) and identify iron deficiency anemia (IDA), prescribe treatment with modern iron preparations. A new generation of ferrous iron preparation with prolonged release is proposed, which minimizes the side effects of therapy. The second aspect is to screen and treat identified coagulation disorders using treatment algorithms based on thromboelastometry data, the third is in the postpartum/postoperative period, screen for and treat iron deficiency and anemia, control coagulation, monitor blood loss and rational use of allogeneic blood components. The results of the introduction of PBM into clinical practice of the National Medical Research Center for Obsterics, Gynecology and Perinatology named after Academician V.I. Kulakov, which allows for timely diagnosis of ID and IDA at the “Anemia-STOP!” Center, rational transfusion of allogeneic blood components, which contributed to a reduction in the volume of procured and transfused donor blood components.
Conclusion. The implementation of the PBM concept helps to improve the effectiveness and safety of treatment, while promoting the best use of economic resources.
Keywords
About the Authors
T. A. FedorovaRussian Federation
4 Oparina Str., Moscow, 117997
E. V. Strelnikova
Russian Federation
4 Oparina Str., Moscow, 117997
References
1. Shander A., Hardy J.F., Ozawa S., Farmer S.L. et al.; Collaborators. A global definition of patient blood management. Anesth. Analg. 2022;135(3):476–88 DOI: 10.1213/ANE.0000000000005873
2. Isbister J., Pearce B.L., Delaforce A.S., Farmer S.L. Patients’ choice, consent, and ethics in patient blood management. Anesth. Analg. 2022;135(3):489–500. DOI: 10.1213/ANE.0000000000006105
3. Levy J.H., Welsby I., Goodnough L.T. Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy. Transfusion. 2014;54(5):1389–405; quiz 1388. DOI: 10.1111/trf.12431
4. McNamara H., Kenyon C., Smith R., Mallaiah S. et al. Four years' experience of a ROTEM-guided algorithm for treatment of coagulopathy in obstetric haemorrhage. Anaesthesiat. 2019;74(8):984–91. DOI: 10.1111/anae.14628
5. Obore N., Liuxiao Z., Haomin Y., Yuchen T. et al. Intraoperative cell salvage for women at high risk of postpartum hemorrhage during cesarean section: a systematic review and meta-analysis. Reprod. Sci. 2022;29(11):3161–76. DOI: 10.1007/s43032-021-00824-8
6. Kaserer A., Castellucci C., Henckert D., Breymann C. et al. Patient blood management in pregnancy. Transfus. Med. Hemother. 2023;50(3):245–55. DOI: 10.1159/000528390
7. Munoz M., Peña-Rosas J.P., Robinson S., Milman N. et al. Patient blood management in obstetrics: management of anaemia and haematinic deficiencies in pregnancy and in the post-partum period: NATA consensus statement. Transfus. Med. 2018;28(1):22–39. DOI: 10.1111/tme.12443
8. Muñoz M., Stensballe J., Ducloy-Bouthors A.S., Bonnet M.-P. et al. Patient blood management in obstetrics: prevention and treatment of postpartum haemorrhage. A NATA consensus statement. Blood Transfus. 2019;17(2):112–36. DOI: 10.2450/2019.0245-18
9. Means R.T. Iron deficiency and iron deficiency anemia: implications and impact in pregnancy, fetal development, and early childhood parameters. Nutrients. 2020;12(2):447. DOI: 10.3390/nu12020447
10. Stevens G.A., Finucane M.M., De-Regil L.M., Paciorek C.J. et al. Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995–2011: a systematic analysis of population-representative data. Lancet Glob. Health. 2013;1(1):e16–25. DOI: 10.1016/S2214-109X(13)70001-9
11. Pavord S., Daru J., Prasannan N., Robinson S. et al.; BSH Committee. UK Guidelines on the management of iron deficiency in pregnancy. Br. J. Haematol. 2020;188(6):819–30. DOI: 10.1111/bjh.16221
12. Milman N. Postpartum anemia I: definition, prevalence, causes, and consequences. Ann. Hematol. 2011;90:1247–53 DOI: 10.1007/s00277-011-1279-z
13. Stuklov N.I. Iron-deficiency anemia in gynecological practice: algorithms for diagnosis, prevention, and treatment. Obstetrics and Gynecology. 2016;7:99–104. (in Russian). DOI: 10.18565/aig.2016.7.99-104
14. Pavlova V.Yu., Smolkov M.A. Anemia of chronic disease. Lechaschy Vrach. 2021;3(24):51–5. (in Russian). DOI: 10.51793/OS.2021.24.3.010
15. Smirnov O.A. Iron-regulatory liver hormone hepcidin and its place in the system of congenital immunity. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2010;20(5):10–15. (in Russian)
16. Peña-Rosas J.P., De-Regil L.M., Gomez Malave H., Flores-Urrutia M.C. et al. Intermittent oral iron supplementation during pregnancy. Cochrane Database Syst. Rev. 2015;2015(10):CD009997. DOI: 10.1002/14651858.CD009997.pub2
17. Okam M.M., Koch T.A., Tran M.H. Iron supplementation, response in iron-deficiency anemia: analysis of five trials. Am. J. Med. 2017;130(8):991 e1–8. DOI: 10.1016/j.amjmed.2017.03.045
18. Serati M., Torella M. Preventing complications by persistence with iron replacement therapy: a comprehensive literature review. Curr. Med. Res. Opin. 2019;35(6):1065–72. DOI: 10.1080/03007995.2018.1552850
19. Krafft A., Perewusnyk G., Hänseler E., Quack K. et al. Effect of postpartum iron supplementation on red cell and iron parameters in non-anaemic iron-deficient women: a randomised placebo controlled study. BJOG. 2005;112(4):445–50. DOI: 10.1111/j.1471-0528.2005.00301.x
20. Cancelo-Hidalgo M.J., Castelo-Branco C., Placios S., Haya-Palazuelos J. et al. Tolerability of different oral iron supplements: a systematic review. Curr. Med. Res. Opin. 2013;29(4):291–303. DOI: 10.1185/03007995.2012.761599
21. Serati M., Cetin I., Athanasiou S. Recovery after surgery: do not forget to check iron status before. Int. J. Womens Health. 2019:11:481–7. DOI: 10.2147/IJWH.S213822
22. Leary A., Barthe L., Clavel T., Sanchez C. et al. Iron pharmacokinetics in women with iron deficiency anemia following a single oral dose of a novel formulation of Tardyferon (prolonged release ferrous sulphate). Drug Res. (Stuttg). 2017;67(11):647–52. DOI: 10.1055/s-0043-113636
23. Milman N., Paszkowski T., Cetin I., Castelo-Branco C. Supplementation during pregnancy: beliefs and science. Gynecol. Endocrinol. 2016;32(7):509–16. DOI: 10.3109/09513590.2016.1149161
24. Dobrokhotova Yu.E., Markova E.A. Peroral retard iron preparation for iron-deficiency anemia: case study and pharmacoeconomic analysis. Russian Journal of Woman and Child Health. 2020;3:1–7. (in Russian). DOI: 10.32364/2618-8430-2020-3-2-88-9422
25. Dobrokhotova Yu.E., Markova E.A. New treatment options for iron deficiency in women of different ages. Russian Journal of Woman and Child Health. 2022;5(3):201–8. (in Russian). DOI: 10.32364/2618-8430-2022-5-3-201-208
26. Kutsenko I.I., Kravtsova E.I., Kholina L.A., Tomina O.V. Latent iron deficiency therapy in pregnant women. Gynecology. 2022;24(6):512–17. (in Russian). DOI: 10.26442/20795696.2022.6.202023
27. Jose A., Mahey R., Sharma J.B., Bhatla N. et al. Comparison of ferric Carboxymaltose and iron sucrose complex for treatment of iron deficiency anemia in pregnancy — randomised controlled trial. BMC Pregnancy Childbirth. 2019;19(1):54. DOI: 10.1186/s12884-019-2200-3
28. Rognoni С., Venturini S., Meregaglia M., Marmifero М. et al. Efficacy and safety of ferric carboxymaltose and other formulations in iron-deficient patients: a systematic review and network metaanalysis of randomised controlled trials. Clin. Drug Investig. 2016;36(3):177–94. DOI: 10.1007/s40261-015-0361-z
29. Frietsch T., Shander A., Faraoni D., Hardy J.F. Patient blood management is not about blood transfusion: it is about patients’ outcomes. Blood Transfus. 2019;17:331–3. DOI: 10.2450/2019.0126-19
30. Ho K.M., Pavey W. Applying the cell-based coagulation model in the management of critical bleeding. Anaesth. Intens. Care. 2017;45(2):166–76. DOI: 10.1177/0310057X1704500206
31. Amgalan A., Allen Т., Othman М., Ahmadzia H.K. Systematic review of viscoelastic testing (TEG/ROTEM) in obstetrics and recommendations from the women's SSC of the ISTH. J. Thromb. Haemost. 2020;18(8):1813–38. DOI: 10.1111/jth.14882
32. Armstrong S., Fernando R., Ashpole K., Simons R. et al. Assessment of coagulation in the obstetric population using ROTEM thromboelastometry. Int. J. Obstet. Anesth. 2011;20(4):293–8. DOI: 10.1016/j.ijoa.2011.05.004
33. Lier H., von Heymann C., Korte W., Schlembach D. Peripartum haemorrhage: haemostatic aspects of the new German PPH guideline. Transfus. Med. Hemother. 2018;45(2):127–35. DOI: 10.1159/000478106
34. Chakladar A., Fludder V., Sugavanam A. Association of anaesthetists recommendations for cell salvage in obstetric anaesthesia. Anaesthesia. 2018;73(12):1575–6. DOI: 10.1111/anae.14488
35. Goobie S.M. Patient blood management is a new standard of care to optimize blood health. Anesth. Analg. 2022;135(3):443–6. DOI: 10.1213/ANE.000000000000618
36. Hoffman A., Shander A., Blumberg N., Hamdorf J.M. et al. Patient blood management: improving outcomes for millions while saving billions. What is holding it up? Anesth. Analg. 2022;135(3):511–23. DOI: 10.1213/ANE.0000000000006138
Review
For citations:
Fedorova T.A., Strelnikova E.V. Patient Blood Management Conception in the Practice of an Obstetrician-Gynecologist: What to Pay Attention to? Title. 2024;23(5):56-61. (In Russ.) https://doi.org/10.31550/1727-2378-2024-23-5-56-61