Difficult Issues in the Diagnosis of Neonatal Lupus Syndrome
https://doi.org/10.31550/1727-2378-2024-23-6-81-87
Abstract
Aim. To describe a clinical case of neonatal lupus with skin syndrome, a retrospective assessment of the significance and genesis of episodes of sinus bradycardia, recorded in utero and persisted postnatally, and neutropenia in the neonatal period.
Key points. Neonatal lupus is a rare syndrome characterized by transient dermatitis, various systemic disorders, hematological changes and/ or congenital fetal heart block. At its core, this is a model of a passively acquired transient immune disease of newborns, which is based on the transplacental transfer of specific maternal antibodies represented exclusively by immunoglobulin G through the Fc receptors of the trophoblast. Difficulties for diagnosis represent neonatal lupus cases with minimal clinical manifestations in a newborn from a mother without an established diagnosis of rheumatic disease.
Conclusion. In the isolated cutaneous form of neonatal lupus syndrome, specific treatment is not required; observation by a pediatrician with monitoring of a blood test confirming the elimination of maternal antibodies is indicated. However, taking into account the possibility of damage to the conduction system of the heart, registration of a surface electrocardiogram and regular monitoring (at least once every 6 months) of 24-hour electrocardiogram monitoring data are necessary.
About the Authors
N. A. Pekareva
National Medical Research Center for Obsterics, Gynecology and Perinatology named after Academician V.I. Kulakov
Russian Federation
Russian Federation
4 Oparina Str., Moscow, 117997
E. L. Bokerija
National Medical Research Center for Obsterics, Gynecology and Perinatology named after Academician V.I. Kulakov; I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
4 Oparina Str., Moscow, 117997; 19 Bolshaya Pirogovskaya Str., build. 1, Moscow, 119435
V. S. Pavlova
National Medical Research Center for Obsterics, Gynecology and Perinatology named after Academician V.I. Kulakov
Russian Federation
Russian Federation
4 Oparina Str., Moscow, 117997
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Review
For citations:
Pekareva N.A., Bokerija E.L., Pavlova V.S. Difficult Issues in the Diagnosis of Neonatal Lupus Syndrome. Title. 2024;23(6):81-87. (In Russ.) https://doi.org/10.31550/1727-2378-2024-23-6-81-87
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