Perinatal Neuroprotection Strategy in Children: Current State of the Problem and Prospects
https://doi.org/10.31550/1727-2378-2024-23-3-49-54
Abstract
Aim. To determine the existing possibilities for protecting the brain in children during an unfavorable course of the perinatal period.
Key points. Injury of the central nervous system are one of the most common pathological conditions in the neonatal period. The article presents modern data on the pathogenesis of perinatal brain injury. Characteristics of various therapeutic and preventive strategies for perinatal neuroprotection are given, modern methods and candidate drugs for providing it are described. Particular attention is paid to their mechanisms of action, as well as advantages and disadvantages.
Conclusion. Additional strategies for the prevention and treatment of brain injury are urgently needed for improve the outcome and prognosis of preterm and full-term neonates.
Keywords
Supporting agencies: The reported study was funded by RFBR, project number 20-315-90067.
About the Authors
E. B. Pavlinova
Omsk State Medical University
Russian Federation
Russian Federation
77 Kuybyshev Str., Omsk, 644001
A. A. Gubich
Omsk State Medical University
Russian Federation
Russian Federation
77 Kuybyshev Str., Omsk, 644001
O. A. Savchenko
Omsk State Medical University
Russian Federation
Russian Federation
77 Kuybyshev Str., Omsk, 644001
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Review
For citations:
Pavlinova E.B., Gubich A.A., Savchenko O.A. Perinatal Neuroprotection Strategy in Children: Current State of the Problem and Prospects. Title. 2024;23(3):49-54. (In Russ.) https://doi.org/10.31550/1727-2378-2024-23-3-49-54
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