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Frequency of Occurrence, Main Risk Factors and Effectiveness of Treatment of Patients with Postpartum Hemorrhage

https://doi.org/10.31550/1727-2378-2023-22-5-14-19

Abstract

   Aim: to evaluate the frequency of postpartum hemorrhage (PPH) in a high risk hospital, to conduct a comparative assessment of the clinical, historical and laboratory features of patients with PPH, and the effectiveness of the algorithm of PPH management after vaginal birth (VB) and caesarean section (CS).

   Design: retrospective study.

   Material and methods. The study included 15,480 patients. The frequency of early PPH and the effectiveness of applying a local stepwise algorithm for management of PPH were evaluated. Clinical historical and laboratory data were obtained by copying from the primary documentation.

   Results. The incidence of PPH in a high risk hospital is 0.67 %. The most significant risk factor for PPH is the induction of labor, but more than a third of women do not have significant risk factors. The volume of blood loss after CS was 1218.29 ± 728.15 ml, after VB — 784.12 ± 304.44 ml (p < 0.001). Uterine balloon tamponade was used in 28 (44.4 %) women with PPH after VB and in 27 (65.9 %) after CS (χ2 = 4.600; p = 0.142). Compression sutures on the uterus were used in 12 (29.3 %) patients after CS and in 3 (2.9 %) puerperas after VB (χ2 = 2.8; p = 0.001). Hysterectomy was performed in 4 (9.8 %) cases only after CS.

   Conclusion: The existing algorithms for management PPH are highly effective and allow avoiding hysterectomy in VB in 100 % of cases, in CS — in 90.2 %.

About the Authors

N. V. Artymuk
Kemerovo State Medical University
Russian Federation

650056; 22a Voroshilov Str.; Kemerovo



T. Yu. Marochko
Kemerovo State Medical University
Russian Federation

650056; 22a Voroshilov Str.; Kemerovo



S. V. Apresyan
Peoples' Friendship University of Russia named after Patris Lumumba
Russian Federation

117198; 6 Miklukho-Maklay Str.; Moscow



D. A. Artymuk
Peoples' Friendship University of Russia named after Patris Lumumba
Russian Federation

117198; 6 Miklukho-Maklay Str.; Moscow



N. M. Shibelgut
Kuzbass Regional Clinical Hospital named after S.V. Belyaev
Russian Federation

650066; 22 Oktyabrsky prosp.; Kemerovo



N. A. Batina
Kuzbass Regional Clinical Hospital named after S.V. Belyaev
Russian Federation

650066; 22 Oktyabrsky prosp.; Kemerovo



A. A. Khludentsova
Kemerovo State Medical University
Russian Federation

650056; 22a Voroshilov Str.; Kemerovo



References

1. Andrikopoulou M., D'Alton M.E. Postpartum hemorrhage: early identification challenges. Semin. Perinatol. 2019;43(1):11–17. DOI: 10.1053/j.semperi.2018.11.003

2. Evensen A., Anderson J.M., Fontaine P. Postpartum hemorrhage: prevention and treatment. Am. Fam. Physician. 2017;95(7):442–449.

3. Mavrides E., Allard S., Chandraharan E. et al. Prevention and management of postpartum haemorrhage. BJOG An. Int. J. Obstet. Gynaecol. 2017;124(5):e106–e149. DOI: 10.1111/1471-0528.141784.

4. ACOG Committee on Practice Bulletins-Obstetrics. Practice Bulletin No. 183: Postpartum Hemorrhage. Obstet. Gynecol. 2017;130(4):168–186. DOI: 10.1097/AOG.0000000000002351

5. Russell R.T. WHO guidelines for the management of postpartum haemorrhage and retained placenta. Hum. Fertil. 2011;14(2):129–129. DOI: 10.3109/14647273.2010.529650

6. Рostpartum hemorrhage. Сlinical recommendations. Moscow, 2021.

7. Ziganshin A.M., Bektasheva I.I., Mudrov V.A. Uterotonic drugs in the prevention and treatment of obstetric bleeding. Journal of Obstetrics and Women's Diseases. 2021;70(1):77–88. DOI: 10.17816/JOWD55045

8. Rostovtsev A.V., Aleksandrovich Yu.S., Ryazanova O.V. et al. Terotonic therapy for hypotonic postpartum hemorrhage. Bulletin of anesthesiology and resuscitation. 2022;19(6):97–105. DOI: 10.21292/2078-5658-2022-19-6-97-105

9. Kansurova M.R., Rymashevsky A.N., Volkov A.E. Rationale for the use of a new compression suture to stop hypotonic bleeding in puerperas. Siberian Medical Review. 2022;(4):66–72. DOI: 10.20333/25000136-2022-4-66-72

10. Artymuk N.V., Marochko T.Yu., Artymuk D.A. The effectiveness of controlled balloon tamponade in the treatment of postpartum hemorrhage. Mother and Child in Kuzbass. 2021;(1):77–81. DOI: 10.24411/2686-7338-2021-10009

11. Babazhanova Sh.D., Lyubchich A.S., Lyubchich N.I. Efficiency of using controlled balloon tamponade to stop postpartum atonic bleeding. Journal of Obstetrics and Women's Diseases. 2022;71(1):5–10. DOI: 10.17816/JOWD46050

12. Eskaraeva A.B. Current methods of diagnosis, management and treatment of postpartum hemorrhage. The use of tranexamic acid and uterine balloon tamponade in healthcare systems of the CIS countries. Best research work 2022: collection of articles of the III International Research Competition, Penza, February 10, 2022. Penza, 2022:184–190.

13. Magann E.F., Doherty D.A., Briery C.M. et al. Obstetric characteristics for a prolonged third stage of labor and risk for postpartum hemorrhage. Gynecol. Obstet. Invest. 2008;65(3):201–205. DOI: 10.1159/000112227

14. Balki M., Downey K., Walker A. et al. Prophylactic administration of uterotonics to prevent postpartum hemorrhage in women undergoing cesarean delivery for arrest of labor: a randomized controlled trial. Obstet. Gynecol. 2021;137(3):505–513. DOI: 10.1097/AOG.0000000000004288

15. Bektemir K.Z., Shoonaeva N.D. Postpartum hemorrhage — an actual problem in modern obstetrics. Science, new technologies and innovations of Kyrgyzstan. 2022;(4):131–136. DOI: 10.26104/NNTIK.2022.16.24.029

16. RF patent 2797734, IPC A61B 17/42 (2006.01), A61M 25/10 (2013.01), A61M 3/00 (2006.01), A61K 38/095 (2019.01), A61P 15/00 (2006.01). A method for preventing postpartum hemorrhage during cesarean section in high-risk patients (placenta previa, uterine scar failure): No. 2023111344: Appl. 05/02/2023: publ. 06/08/2023 / Artymuk N.V., Marochko T.Yu., Kolesnikova N.B. et al. 3 p.

17. Feduniw S., Warzecha D., Szymusik I., Wielgos M. Epidemiology, prevention and management of early postpartum hemorrhage — a systematic review. Ginekol. Pol. 2020;91(1):38–44. DOI: 10.5603/GP.2020.0009

18. Ehrenthal D.B., Chichester M.L., Cole O.S., Jiang X. Maternal risk factors for peripartum transfusion. J. Womens Health (Larchmt). 2012;21(7):792–797.

19. Ende H.B., Lozada M.J., Chestnut D.H. et al. Risk factors for atonic postpartum hemorrhage : a systematic review and meta-analysis. Obstet. Gynecol. 2021;137(2):305–323. DOI: 10.1097/AOG.0000000000004228

20. Paredes C., Hsu R.C., Tong A., Johnson J.R. Obesity and pregnancy. Neoreviews. 2021;22(2):e78–e87. DOI: 10.1542/neo.22-2-e78

21. Kramer M.S., Berg C., Abenhaim H. et al. Incidence, risk factors, and temporal trends in severe postpartum hemorrhage. Am. J. Obstet. Gynecol. 2013;209:1–7.

22. Kamenskikh G.V., Novikova V.A. The possibilities of predicting bleeding in women with premature birth. Scientific review. Medical sciences. 2019;(2):63–73.

23. Radzinsky V.E., Doronina O.K., Startseva N.M. et al. Induction of labor with mifepristone and intracervical balloon catheter. Bulletin of KazNMU. 2022;(2):103–114.

24. Suarez S., Conde-Agudelo A., Borovac-Pinheiro A. et al. Uterine balloon tamponade for the treatment of postpartum hemorrhage : a systematic review and meta-analysis. Am. J. Obstet. Gynecol. 2020;222(4):293.e1–293.e52. DOI: 10.1016/j.ajog.2019.11.1287

25. Goffman D., Nathan L., Chazotte C. Obstetric hemorrhage : a global review. Semin. Perinatol. 2016;40(2):96–98. DOI: 10.1053/j.semperi.2015.11.014

26. Raspopin Yu.S., Shifman E.M., Belinina A.A. et al. Efficiency and safety of terlipressin application during caesarian section in pregnant women with a high risk of bleeding : a multicenter comprehensive cohort study of Terli-Bleed. Part I. Gynecology, Obstetrics and Perinatology. 2021;20(1):11–20. DOI: 10.20953/1726-1678-2021-1-11-20

27. Raspopin Yu.S., Shifman E.M., Belinina A.A. et al. Efficiency and safety of terlipressin application during caesarian section in pregnant women with a high risk of bleeding: a multicenter comprehensive cohort study of Terli-Bleed. Part II. Gynecology, Obstetrics and Perinatology. 2021;20(2):26–32. DOI: 10.20953/1726-1678-2021-2-26-32


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For citations:


Artymuk N.V., Marochko T.Yu., Apresyan S.V., Artymuk D.A., Shibelgut N.M., Batina N.A., Khludentsova A.A. Frequency of Occurrence, Main Risk Factors and Effectiveness of Treatment of Patients with Postpartum Hemorrhage. Title. 2023;22(5):14-19. (In Russ.) https://doi.org/10.31550/1727-2378-2023-22-5-14-19

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