Problem of Vitamin D Levels in Obese Children
https://doi.org/10.31550/1727-2378-2022-21-3-45-49
Abstract
Study Objective: To assess the relationship between vitamin D level and bone ultrasonometry and bone metabolism markers in obese children.
Study Design: Prospective controlled trial.
Materials and Methods. We examined obese (study group, n = 31) and normal (control group, n = 40) children aged 4 to 15.
We reviewed medical records of children (form No. 112-1/у-00); conducted physical examination including assessment of physical development; and measured bone density (ultrasound osteodensitometry) and serum 25(ОН)D concentration (chemilumescent analysis).
Study Results. The study group demonstrated statistically significant (р < 0.05) reduction in vitamin D levels and bone density vs controls. All obese children had vitamin D insufficiency or deficit. The deficit of vitamin D was associated with a lower bone density, reduced markers of osseogenesis and increased markers of bone resorption: osteocalcin concentration was 19.8 [14.5; 23.6] ng/mL vs 84.0 [68.9; 102.9] ng/mL in controls (р < 0.001), β-CrossLaps — 2.0 [0.9; 4.2] vs 0,5 [0.3; 0.5] ng/mL (р < 0.001), alkaline phosphatase — 457 [277; 581] vs 262 [232; 453] U/L (р < 0.05).
Conclusion. Paediatric obesity is a risk factor of vitamin D deficit. which, in turn, is a risk factor of osteoporosis. Therefore, prevention of vitamin D deficiency is essential.
About the Authors
A. S. Efremenkova
Smolensk State Medical University of the Ministry of Health of the Russian Federation; Smolensk Children Clinical Hospital
Russian Federation
Russian Federation
28 Krupskaya Str., Smolensk, 214019; 8 12 let Oktyabriya Str., Smolensk, 214012
N. Yu. Krutikova
Smolensk State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
28 Krupskaya Str., Smolensk, 214019
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Review
For citations:
Efremenkova A.S., Krutikova N.Yu. Problem of Vitamin D Levels in Obese Children. Title. 2022;21(3):45-49. (In Russ.) https://doi.org/10.31550/1727-2378-2022-21-3-45-49
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