SARS-CoV-2 Vaccination of Pregnant Women during the 2020-2023 Pandemic: Implications for Obstetric and Perinatal Outcomes
https://doi.org/10.31550/1727-2378-2025-24-5-68-73
Abstract
Aim. A review of scientific literature data on vaccination of patients at the preconception stage and during pregnancy, the effect of the domestic vaccine against COVID-19 on the development of obstetric and perinatal complications, as well as a study of the dynamics of vaccination in the regions of the Russian Federation.
Key points. The problem of vaccinating pregnant patients, as well as women planning pregnancy, against a new coronavirus infection is extremely relevant in connection with the recent COVID-19 pandemic and its negative impact on public health. Women during pregnancy and the postpartum period are at high risk of severe disease and the development of obstetric and perinatal complications. In addition, a new coronavirus infection suffered before pregnancy may lead to an increased risk of gestational complications. Despite recommendations from leading world and Russian medical organizations about the need to vaccinate pregnant women who are at highest risk of severe COVID-19, the proportion of vaccinated patients remains insignificant. An obstacle to widespread vaccination in the pregnant population is a lack of information and misinformation about the risks associated with vaccination in relation to the health of the mother and fetus. Vaccination coverage among pregnant women in the Russian Federation is insufficient to achieve herd immunity.
Conclusion. Vaccination against the new coronavirus infection is an effective method of preventing severe COVID-19, obstetric and perinatal complications and does not have a negative impact on the mother’s health. However, in the modern scientific literature there is insufficient data on the impact of vaccination against COVID-19 on the course of pregnancy, the health of the fetus and newborn, so these issues remain relevant and require further research.
About the Authors
E. B. Efimkova
Moscow Regional Research Institute of Obstetrics and Gynecology named after academician V.I. Krasnopolsky
Russian Federation
Russian Federation
Moscow
E. V. Dulaeva
Moscow Regional Research Institute of Obstetrics and Gynecology named after academician V.I. Krasnopolsky
Russian Federation
Russian Federation
Moscow
O. N. Kravtsova
Moscow Regional Research Institute of Obstetrics and Gynecology named after academician V.I. Krasnopolsky
Russian Federation
Russian Federation
Moscow
References
1. Sinchikhin S.P., Bragina G.S., Parshina O.V., Stepanyan L.V. et al. Current state of COVID-19 in pregnancy. Gynecology. 2022;24(3):206–11. (in Russian). DOI: 10.26442/20795696.2022.3.201671
2. Kimberlin D.W., Stagno S. Can SARS-CoV-2 infection be acquired in utero? More definitive evidence is needed. JAMA. 2020;323(18):1788–9. DOI: 10.1001/jama.2020.4868
3. Jafari M., Pormohammad A., Sheikh Neshin S.A., Ghorbani S. et al. Clinical characteristics and outcomes of pregnant women with COVID-19 and comparison with control patients: a systematic review and meta-analysis. Rev. Med. Virol. 2021;31(5):1–16. DOI: 10.1002/rmv.2208
4. Juliá-Burchés C., Martínez-Varea A. An update on COVID-19 vaccination and pregnancy. J. Personal. Med. 2023;13(5):797. DOI: 10.3390/jpm13050797
5. Jamieson D.J., Rasmussen S.A. An update on COVID-19 and pregnancy. Am. J. Obstet. Gynecol. 2022;226(2):177–86. DOI: 10.1016/j.ajog.2021.08.054
6. Huntley B.J.F., Huntley E.S., Di Mascio D., Chen T. et al. Rates of maternal and perinatal mortality and vertical transmission in pregnancies complicated by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Co-V-2) infection: a systematic review. Obstet. Gynecol. 2020;136(2):303–12. DOI: 10.1097/AOG.0000000000004010
7. Morgan J.A., Biggio J.R. Jr, Martin J.K., Mussarat N. et al. Pregnancy outcomes in patients after completion of the mRNA coronavirus disease 2019 (COVID-19) vaccination series compared with unvaccinated patients. Obstet. Gynecol. 2023;141(3):555–62. DOI: 10.1097/AOG.0000000000005072
8. Hantoushzadeh S., Shamshirsaz A.A., Aleyasin A., Nouri B. et al. Maternal death due to COVID-19 disease. Am. J. Obstet. Gynecol. 2020;223(1):109.e1–16. DOI: 10.1016/j.ajog.2020.04.030
9. Kuneshko N.F., Kim V.V. The impact of past coronovirus infection on the development, course and outcome of pregnancy. Medicine. Sociology. Philosophy. Applied Research. 2022;3:22–7. (in Russian)
10. Dolgushina N.V., Drapkina Yu.S., Krechetova L.V., Ivanets T.Yu. et al. Gam-COVID-Vac (Sputnik V) vaccine has no adverse effect on ovarian reserve in reproductive-age women. Obstetrics and Gynecology. 2021;7:81–7. (in Russian). DOI: 10.18565/aig.2021.7.81-86
11. Dolgushina N.V., Dovgan A.A., Drapkina Yu.S., Ivanets T.Yu. et al. The effect of the russian combined vector vaccine against the novel coronavirus infection caused by SARS-CoV-2 on ovarian reserve and menstrual function in reproductive-aged women. Obstetrics and Gynecology. 2022;4: 115–22. (in Russian). DOI 10.18565/aig.2022.4.115-122
12. Zaigham M., Andersson O. Maternal and perinatal outcomes with COVID-19: a systematic review of 108 pregnancies. Acta Obstet. Gynecol. Scand. 2020;99(7):823–9. DOI: 10.1111/aogs.13867
13. Drapkina O.M., Berns S.A., Gorshkov A.Yu., Ryzhakova L.N. et al. Association of humoral immunity status and thrombodynamics after vaccination with Gam-COVID-Vac and CoviVac. Cardiovascular Therapy and Prevention. 2022;21(6):3295. (in Russian). DOI: 10.15829/1728-8800-2022-3295
14. Alzamora M.C., Paredes T., Caceres D., Webb C.M. et al. Severe COVID-19 during pregnancy and possible vertical transmission. Am. J. Perinatol. 2020;37(8):861–5. DOI: 10.1055/s-0040-1710050
15. Dong L., Tian J., He S., Zhu C. et al. Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. JAMA. 2020;323(18):1846–8. DOI: 10.1001/jama.2020.4621
16. Efimkova E.B., Novikova S.V., Dulaeva E.V., Chechneva M.A. et al. Haemostatic parameters in pregnant women with a new coronavirus infection COVID-19. Russian Bulletin of Obstetrician-Gynecologist. 2023;23(1):47–55. (in Russian). DOI: 10.17116/rosakush20232301147
17. Mendoza M., Garcia-Ruiz I., Maiz N., Rodo C. et al. Pre-eclampsia-like syndrome induced by severe COVID-19: a prospective observational study. BJOG. 2020;127(11):1374–80. DOI: 10.1111/1471-0528.16339
18. Vivanti A.J., Vauloup-Fellous C., Prevot S., Zupan V. et al. Transplacental transmission of SARS-CoV-2 infection. Nat. Commun. 2020;11(1):3572. DOI: 10.1038/s41467-020-17436-6
19. Sathiya R., Rajendran J., Sumathi S. COVID-19 and preeclampsia: overlapping features in pregnancy. Rambam Maimonides Med. J. 2022;13(1):e0007. DOI: 10.5041/RMMJ.10464
20. Gray K.J., Bordt E.A., Atyeo C., Deriso E. et al. Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study. Am. J. Obstet. Gynecol. 2021;225(3):303.e1–17. DOI: 10.1016/j.ajog.2021.03.023
21. Goldshtein I., Nevo D., Steinberg D.M., Rotem R.S. et al. Association between BNT162b2 vaccination and incidence of SARS-CoV-2 infection in pregnant women. JAMA. 2021;326(8):728–35. DOI: 10.1001/jama.2021.11035
22. Hui L., Marzan M.B., Rolnik D.L., Potenza S. et al. Reductions in stillbirths and preterm birth in COVID-19-vaccinated women: a multicenter cohort study of vaccination uptake and perinatal outcomes. Am. J. Obstet. Gynecol. 2023;228(5):585.e1–16. DOI: 10.1016/j.ajog.2022.10.040
23. Hadj Hassine I. COVID-19 vaccines and variants of concern: a review. Rev. Med. Virol. 2022;32(4):e2313. DOI: 10.1002/rmv.2313
24. Rasmussen S.A., Jamieson D.J., Bresee J.S. Pandemic influenza and pregnant women. Emerg. Infect. Dis. 2008;14(1):95–100. DOI: 10.3201/eid1401.070667
25. Logunov D.Y., Dolzhikova I.V., Zubkova O.V., Tukhvatullin A.I. et al. Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia. Lancet. 2020;396(10255):887–97. DOI: 10.1016/S0140-6736(20)31866-3
26. Logunov D.Y., Dolzhikova I.V., Shcheblyakov D.V., Tukhvatulin A.I. et al. Gam-COVID-Vac Vaccine Trial Group. Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia. Lancet. 2021;397(10275):671–81. (in Russian). DOI: 10.1016/S0140-6736(21)00234-8
27. Sukhikh G.T., Dolgushina N.V., Shmakov R.G., Klimov V.A. et al. Pregnancy outcomes after maternal COVID-19 vaccination during pregnancy: preliminary. Obstetrics and Gynecology. 2021;11:5–8. (in Russian). DOI: 10.18565/aig.2021.11.5-8
28. Yavorskaya S.D., Dmitrienko K.V., Orlova D.V., Dolgova N.S. et al. Obstetric and perinatal outcomes of patients vaccinated against COVID-19 in the preconception period and during pregnancy. Bulletin of the DSMA. 2023;2(47):35–41. (in Russian)
29. Еlgina S.I., Migulko D.A., Kadashnikova K.V., Tretyakova S.V. et al. The effect of vaccination against COVID-19 on pregnancy and childbirth outcomes. Mother and Baby in Kuzbass. 2023;4(95): 31–4. (in Russian). DOI: 10.24412/2686-7338-2023-4-31-34
30. Artymuk N.V., Parfenova Ya.A., Tachkova O.A. Trends of vaccination against COVID-19 among pregnant women in Siberia. Fundamental and Clinical Medicine. 2022;7(1): 86–91. (in Russian). DOI: 10.23946/2500-0764-2022-7-1-86-91
31. Artymuk N.V., Belokrinitskaya T.E., Parfenova Ya.A., Frolova N.I. Monitoring of COVID-19 vaccination in pregnant women of Siberia and the Russian Far East. Obstetrics and Gynecology. 2022;5:53–8. (in Russian). DOI: 10.18565/aig.2022.5.53-58
Review
For citations:
Efimkova E.B., Dulaeva E.V., Kravtsova O.N. SARS-CoV-2 Vaccination of Pregnant Women during the 2020-2023 Pandemic: Implications for Obstetric and Perinatal Outcomes. Title. 2025;24(5):68-73. (In Russ.) https://doi.org/10.31550/1727-2378-2025-24-5-68-73
Views:
9
Email this article 