Potential of Trans-Resveratrol in the Prevention of Menopausal Disorders and Age-Associated Morbidity
https://doi.org/10.31550/1727-2378-2023-22-5-62-68
Abstract
Aim: to investigate alternative option to prevent age-associated pathology in women, caused, by progressive decrease of estrogen level during the menopausal transition period.
Key points. If there are contraindications to the menopausal hormone therapy or at the examination stage, the choice of alternative methods for prevention and treatment of menopausal symptoms and systemic metabolic disorders should correspond to a high safety and efficacy profile. This review describes in detail the pharmacological effects of the phytoestrogen resveratrol, the mechanisms of the implementation of estrogen-like, antiproliferative, anti-inflammatory and antioxidant effects and the possibility of clinical use in the form of dietary supplements.
Conclusion. The prescription of the phytoestrogen trans-resveratrol is an alternative approach to the relief of menopausal disorders and the prevention of systemic metabolic disorders. Possessing as high bio-active and optimal safe alternative due to trans-isomer form, it is the optimal non-hormonal remedy for correcting menopausal symptoms, inhibiting some aging processes, and also has a significant potential for preventing age-related diseases.
Supporting agencies: The author declares that there is no external funding for the exploration and analysis work
About the Author
P. V. Kozlov
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
117997; 1 Ostrovityanova Str.; Moscow
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Kozlov P.V. Potential of Trans-Resveratrol in the Prevention of Menopausal Disorders and Age-Associated Morbidity. Title. 2023;22(5):62-68. (In Russ.) https://doi.org/10.31550/1727-2378-2023-22-5-62-68
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