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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">docru</journal-id><journal-title-group><journal-title xml:lang="ru">Доктор.Ру</journal-title><trans-title-group xml:lang="en"><trans-title>Title</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-2378</issn><issn pub-type="epub">2713-2994</issn><publisher><publisher-name>ООО "ГК "РУСМЕДИКАЛ"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31550/1727-2378-2025-24-4-51-57</article-id><article-id custom-type="elpub" pub-id-type="custom">docru-345</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL PAPERS</subject></subj-group></article-categories><title-group><article-title>Влияние интервальных гипоксических  тренировок на показатели пищевого статуса  при морбидном ожирении</article-title><trans-title-group xml:lang="en"><trans-title>Influence of Interval Hypoxic Training on Indicators of Nutritional Status in Morbid Obesity</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3492-1778</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Залетова</surname><given-names>Т. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Zaletova</surname><given-names>T. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Залетова Татьяна Сергеевна — заведующая дневным стационаром</p><p>г. Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">dr@zaletova.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4367-2232</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зайнудинов</surname><given-names>З. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Zainudinov</surname><given-names>Z. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зайнудинов Зайнудин Мусаевич — главный врач</p><p>г. Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">zain_z@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2349-2218</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Феофанова</surname><given-names>Т. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Feofanova</surname><given-names>T. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Феофанова Татьяна Борисовна — к. м. н., научный сотрудник отделения персонализированной диетотерапии</p><p>г. Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">dr-tanya@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9650-3758</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Монисов</surname><given-names>Ф. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Monisov</surname><given-names>F. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Монисов Филипп Михайлович — соискатель кандидатской степени; врач-ординатор</p><p>г. Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">dr.monisov@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУН «Федеральный исследовательский центр питания и биотехнологии»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center of Nutrition, Biotechnology and Food Safety</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУН «Федеральный исследовательский центр питания и биотехнологии»; ФГБУ «Центральный научно-исследовательский институт организации и информатизации здравоохранения» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center of Nutrition, Biotechnology and Food Safety; Russian Research Institute of Health</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>13</day><month>11</month><year>2025</year></pub-date><volume>24</volume><issue>4</issue><issue-title>КАРДИОМЕТАБОЛИЧЕСКАЯ МЕДИЦИНА</issue-title><fpage>51</fpage><lpage>57</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Залетова Т.С., Зайнудинов З.М., Феофанова Т.Б., Монисов Ф.М., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Залетова Т.С., Зайнудинов З.М., Феофанова Т.Б., Монисов Ф.М.</copyright-holder><copyright-holder xml:lang="en">Zaletova T.S., Zainudinov Z.M., Feofanova T.B., Monisov F.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://docru.elpub.ru/jour/article/view/345">https://docru.elpub.ru/jour/article/view/345</self-uri><abstract><sec><title>Цель</title><p>Цель. Проанализировать влияние интервальных гипоксически-гипероксических тренировок (ИГГТ) на показатели пищевого статуса у лиц с морбидным ожирением.</p></sec><sec><title>Дизайн</title><p>Дизайн. Проспективное одноцентровое нерандомизированное исследование.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В исследование были включены 40 пациентов с морбидным ожирением, которых распределили на две группы: 1-я группа (контрольная) — 20 человек (10 мужчин и 10 женщин), придерживавшихся варианта диеты с повышенным количеством белка (ВБД) и общих рекомендации по оптимальной физической нагрузке; 2-я группа (основная) — 20 человек (10 мужчин и 10 женщин), которым была назначена ВБД в сочетании с ИГГТ. Всем пациентам проводилась оценка клинического статуса, определение состава тела (биоимпедансометрия), биохимических маркеров белкового, липидного, углеводного обмена в плазме крови.</p></sec><sec><title>Результаты</title><p>Результаты. На фоне ИГГТ у обследованных наблюдалось значимое снижение уровня липопротеинов низкой плотности и более выраженное уменьшение содержания глюкозы (5,25 и 5,63 ммоль/л соответственно; p = 0,021), меньшее снижение процента жировой ткани (45,6 и 53,5% соответственно; p = 0,012) и увеличение основного обмена (2314 и 1804 соответственно; p = 0,001) по сравнению с пациентами, которым была назначена только ВБД. Кроме того, в контрольной группе выявлено значимое увеличение уровней мочевой кислоты, эритроцитов и гемоглобина (p &lt; 0,05), чего не наблюдалось в основной группе (p &gt; 0,05).</p></sec><sec><title>Заключение</title><p>Заключение. Добавление ИГГТ к ВБД в курс терапии пациентов с морбидным ожирением безопасно и способствует более выраженному улучшению биохимических параметров крови, показателей биоимпедансометрии и увеличению основного обмена по сравнению с изолированной ВБД. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To analyze the effect of intermittent hypoxic-hyperoxic training (IHHT) on nutritional status indicators in individuals with morbid obesity.</p></sec><sec><title>Design</title><p>Design. Prospective, single-center, non-randomized study.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study included 40 patients with morbid obesity, who were divided into two groups: Group 1 (control) — 20 individuals (10 men and 10 women) adhering to a high-protein diet (HPD) variant and general recommendations for optimal physical activity; Group 2 (main) — 20 individuals (10 men and 10 women) who were prescribed HPD in combination with IHHT. All patients underwent an assessment of clinical status, body composition analysis (bioimpedance analysis), and determination of biochemical markers of protein, lipid, and carbohydrate metabolism in blood plasma.</p></sec><sec><title>Results</title><p>Results. IHHT was associated with a significant decrease in low-density lipoprotein levels and a more pronounced reduction in glucose levels (5.25 and 5.63 mmol/L, respectively; p = 0.021), a smaller decrease in the percentage of body fat (45.6 and 53.5%, respectively; p = 0.012), and an increase in basal metabolic rate (2314 and 1804, respectively; p = 0.001) compared to patients prescribed HPD alone. In addition, the control group showed a significant increase in uric acid, erythrocyte, and hemoglobin levels (p &lt; 0.05), which was not observed in the main group (p &gt; 0.05).</p></sec><sec><title>Conclusions</title><p>Conclusions. The addition of IGHT to HPD in the course of therapy of patients with morbid obesity is safe and promotes a more pronounced improvement of blood biochemical parameters, bioimpedanceometry indices and increase in basal metabolism, compared to isolated HPD.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>морбидное ожирение</kwd><kwd>интервальная гипоксическая тренеровка</kwd><kwd>диета с повышенным количеством белка</kwd><kwd>биоимпедансометрия</kwd><kwd>состав тела</kwd></kwd-group><kwd-group xml:lang="en"><kwd>morbid obesity</kwd><kwd>interval hypoxic training</kwd><kwd>high-protein diet</kwd><kwd>bioimpedanceometry</kwd><kwd>body composition</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Публикация подготовлена в рамках выполнения фундаментальной научно-исследовательской работы ФГБУН «ФИЦ питания и биотехнологии» № FGMF-2022-0005.</funding-statement><funding-statement xml:lang="en">This publication was prepared as part of the implementation of fundamental research work No. FGMF-2022-0005 by the Federal Research Center of Nutrition, Biotechnology and Food Safety.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Sørensen T.I.A., Martinez A.R., Jørgensen T.S.H. 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