docruДоктор.РуTitle1727-23782713-2994ООО "ГК "РУСМЕДИКАЛ"10.31550/1727-2378-2024-23-6-88-92docru-283Research ArticleКЛИНИЧЕСКИЙ ОПЫТCLINICAL EXPERIENCEПредикторы рецидивов бронхиальной обструкции у детей раннего возрастаPredictors of Recurrent Wheezing in Young Childrenhttps://orcid.org/0009-0009-4208-1789МхитарянА. А.MkhitaryanA. A.

Мхитарян Анна Арцруновна — aссистент кафедры педиатрии № 1, врач-педиатр Университетского больничного комплекса «Мурацан» Ереванского государственного медицинского университета им. М. Гераци.

0025, Ереван, ул. Корюна, д. 2

2 Koryun Str., Yerevan, 0025

annamkhitaryan106@gmail.comЕреванский государственный медицинский университет имени Мхитара ГерациАрменияYerevan State Medical University named after Mkhitar HeratsiArmenia202419022025236ПЕДИАТРИЯ8892Copyright © Мхитарян А.А., 20252025Мхитарян А.А.Mkhitaryan A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://docru.elpub.ru/jour/article/view/283Цель обзора

Цель обзора. Представить информацию о предикторах рецидивов бронхиальной обструкции у детей раннего возраста и вероятности развития у них бронхиальной астмы в будущем.

Основные положения

Основные положения. За прошедшие несколько лет опубликованы более 280 работ, подтверждающих важную роль HLA-G в регуляции иммунной системы человека, атигены HLA-G рассматриваются как прогностический фактор развития различных патологических состояний. Показано, что белки HLA-G участвуют в иммунной регуляции патогенеза аутоиммунных и аллергических заболеваний (желудочно-кишечных, кожных, неврологических и ревматологических), а также в возникновении патологии периода беременности.

Заключение

Заключение. Уровень sHLA-G имеет особое значение в развитии воспалительных процессов аллергических заболеваний, в частности бронхиальной астмы, что открывает новые возможности для его использования в качестве важного маркера воспаления. Кроме того, sHLA-G как доступный диагностический показатель может быть эффективно внедрен в систему здравоохранения, он позволит решать задачи прогнозирования аллергических заболеваний и контроля поддерживающей терапии.

Aim

Aim. To provide overview information on predictors of relapses of bronchial obstruction in young children and the likelihood of them developing bronchial asthma in the future.

Key points

Key points. Over the past few years, more than 280 papers have been published confirming the important role of HLA-G in the regulation of the human immune system, indicating HLA-G antigens as a prognostic factor in the development of various pathological conditions. HLA-G proteins have been shown to be involved in the immune regulation of the pathogenesis of autoimmune and allergic diseases, such as gastrointestinal, skin, neurological and rheumatological diseases, as well as in the pathology of pregnancy.

Conclusion

Conclusion. The level of sHLA-G is particularly significant in the development of inflammatory processes in allergic diseases, in particular bronchial asthma, which opens up new opportunities for its use as an important marker of inflammation. In addition, sHLA-G, as an accessible diagnostic indicator, can be effectively introduced into the healthcare system, thereby aiding in the prediction of allergic diseases and monitoring maintenance therapy.

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The authors declare that there are no conflicts of interest present.