docruДоктор.РуTitle1727-23782713-2994ООО "ГК "РУСМЕДИКАЛ"10.31550/1727-2378-2023-22-6-54-59docru-263Research ArticleНЕВРОЛОГИЯNEUROLOGYГенетические предикторы развития вегетативной дисфункцииGenetic Predictors of the Development of Autonomic DysfunctionГазенкампфК. А.GazenkampfK. A.

Газенкампф Кирилл Александрович — ассистент кафедры медицинской генетики и клинической нейрофизиологии Института последипломного образования 

660022, г. Красноярск, ул. Партизана Железняка, д. 1 

1 Partizan Zheleznyak Str., Krasnoyarsk, 660022 

hassenkampf@mail.ruhttps://orcid.org/0000-0001-9946-2878ДоморацкаяЕ. А.DomoratskayaE. A.

Доморацкая Екатерина Алексеевна  — младший научный сотрудник лаборатории медицинской генетики 

660022, г. Красноярск, ул. Партизана Железняка, д. 1 

1 Partizan Zheleznyak Str., Krasnoyarsk, 660022 

e.domorats@yandex.ruhttps://orcid.org/0000-0003-4639-6365ДмитренкоД. В.DmitrenkoD. V.

Дмитренко Диана Викторовна — д. м. н., доцент, заведующая кафедрой медицинской генетики и клинической нейрофизиологии Института последипломного образования, руководитель Неврологического центра эпилептологии, нейрогенетики и исследования мозга Университетской клиники 

660022, г. Красноярск, ул. Партизана Железняка, д. 1 

1 Partizan Zheleznyak Str., Krasnoyarsk, 660022 

mart2802@yandex.ruФГБОУ ВО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской ФедерацииРоссияProf. V.F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityRussian Federation202319022025226НЕВРОЛОГИЯ ПСИХИАТРИЯ5459Copyright © Газенкампф К.А., Доморацкая Е.А., Дмитренко Д.В., 20252025Газенкампф К.А., Доморацкая Е.А., Дмитренко Д.В.Gazenkampf K.A., Domoratskaya E.A., Dmitrenko D.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://docru.elpub.ru/jour/article/view/263Цель исследования

Цель исследования: изучить ассоциацию носительства rs6318 гена HTR2C, rs6313 гена HTR2А, rs4680 гена COMT, rs3785143 гена SLC6A2, rs1799913 гена TPH1, rs7997012 гена HTR2A с развитием невротических расстройств у лиц юношеского возраста, проживающих в Красноярском крае.

Дизайн

Дизайн: сравнительное исследование.

Материалы и методы

Материалы и методы. В исследование включены 133 клинически здоровых добровольца. Возраст участников варьировал от 16 до 24 лет. Молекулярно-генетические исследования проведены на базе лаборатории медицинской генетики ФГБОУ ВО КрасГМУ им. проф. В.Ф. Войно-Ясенецкого Минздрава России. Произведены психологическое тестирование с использованием опросника депрессивной симптоматики Бека, шкалы социально-ситуативной тревоги О. Кондаша в модификации А.М. Прихожана, Госпитальной шкалы тревоги и депрессии, а также исследование ассоциации носительства однонуклеотидных вариантов (ОНВ) rs7997012 гена HTR2A, rs6318 гена HTR2C, rs6313 гена HTR2A, rs4680 гена COMT, rs3785143 гена SLC6A2, rs1799913 гена TPH1 с невротическими нарушениями (тревожностью и субклинической депрессией).

Результаты

Результаты. По данным многофакторного анализа, выявлена ассоциация носительства аллеля G гена COMT (отношение шансов (ОШ) = 2,784; 95% доверительный интервал (ДИ): 1,291–6,001; χ2 = 6,986; р = 0,009) и генотипа АG (ОШ = 2,208; 95% ДИ: 1,032–4,724; χ2 = 16,716; р < 0,001) с субклинической депрессией по суммарному показателю шкалы Бека. Носительство генотипа СС rs1799913 гена ТРН1 повышает риск учебной тревожности в 3 раза (ОШ = 3,011; 95% ДИ: 1,138–7,967; χ2 = 7,622; р = 0,023). Заключение. Носительство аллеля G и генотипа АG rs4680 гена COMT ассоциировано с субклинической депрессией, а носительства генотипа СС rs1799913 гена ТРН1 повышает риск учебной тревожности в 3 раза. Таким образом, ОНВ данных генов можно рассматривать как предикторы невротических расстройств, значимые уже на субклиническом уровне.

Aim

Aim: To study the association of the HTR2C gene rs6318, rs6313 of the HTR2A gene, rs4680 of the COMT gene, rs3785143 of the SLC6A2 gene, rs1799913 of the TPH1 gene, rs7997012 of the HTR2A gene with the development of neurotic disorders in young people living in the Krasnoyarsk Territory.

Design

Design: A comparative study.

Materials and methods

Materials and methods. The study included 133 clinically healthy volunteers. The age of the participants ranged from 16 to 24 years. Molecular genetic studies were carried out on the basis of the Laboratory of Medical Genetics of the V.F. Voino-Yasenetsky Moscow State Medical University of the Ministry of Health of Russia. Psychological testing was performed using the questionnaire of depressive symptoms of Beck, the scale of socio-situational anxiety of O. Kondash in the modification of A.M. Parishioner, Hospital scale of anxiety and depression, as well as carrier study of the association of single nucleotide variants (ONV) rs7997012 of the HTR2A gene, rs6318 of the HTR2C gene, rs6313 of the HTR2A gene, rs4680 of the COMT gene, rs3785143 of the SLC6A2 gene, rs1799913 of the TPH1 gene with neurotic disorders (anxiety and subclinical depression).

Results

Results. According to multivariate analysis, the association of the COMT G gene allele carrier (odds ratio (OR) = 2.784; 95% confidence interval (CI): 1.291–6.001; χ2 = 6.986; p = 0.009) and the AH genotype (OR = 2,208; 95% CI: 1,032–4,724; χ2 = 16.716; p < 0.001) with subclinical depression according to the total index of the Beck scale. Carrying the SS genotype of the rs1799913 TRN1 gene increases the risk of learning anxiety by 3 times (OR = 3.011; 95% CI: 1.138–7.967; χ2 = 7.622; p = 0.023).

Conclusion

Conclusion. The carriage of the G allele and the rs4680 genotype and AG of the COMT gene is associated with subclinical depression, and the carriage of the SS genotype of the rs1799913 TRN1 gene increases the risk of learning anxiety by 3 times. Thus, the ONV of these genes can be considered as predictors of neurotic disorders, significant already at the subclinical level.

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The authors declare that there are no conflicts of interest present.