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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">docru</journal-id><journal-title-group><journal-title xml:lang="ru">Доктор.Ру</journal-title><trans-title-group xml:lang="en"><trans-title>Title</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-2378</issn><issn pub-type="epub">2713-2994</issn><publisher><publisher-name>ООО "ГК "РУСМЕДИКАЛ"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31550/1727-2378-2023-22-5-89-94</article-id><article-id custom-type="elpub" pub-id-type="custom">docru-251</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГИНЕКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GYNECOLOGY</subject></subj-group></article-categories><title-group><article-title>Ведение пациенток с генитальным эндометриозом: новые стратегии</article-title><trans-title-group xml:lang="en"><trans-title>Management of Patients with Genital Endometriosis: New Strategies</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6537-3436</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ермолова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ermolova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наталья Викторовна Ермолова,  д. м. н., доцент, начальник отдела, профессор</p><p>акушерско-гинекологический отдел; кафедра акушерства и гинекологии № 2</p><p>344022; Нахичеванский пер., д. 29; Ростов-на-Дону</p></bio><bio xml:lang="en"><p>344022; 29 Nahichevansky Ave.; Rostov-on-Don</p></bio><email xlink:type="simple">rniiap.ermolova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2348-8809</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петров</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrov</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юрий Алексеевич Петров, д. м. н., профессор, заведующий кафедрой</p><p>кафедра акушерства и гинекологии № 2</p><p>344022; Нахичеванский пер., д. 29; Ростов-на-Дону</p></bio><bio xml:lang="en"><p>344022; 29 Nahichevansky Ave.; Rostov-on-Don</p></bio><email xlink:type="simple">mr.doctorpetrov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8047-7148</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Левкович</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Levkovich</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Марина Аркадьевна Левкович, д. м. н., доцент, ведущий научный сотрудник</p><p>отдел аллергии и аутоиммунных заболеваний</p><p>344022; Нахичеванский пер., д. 29; Ростов-на-Дону</p></bio><bio xml:lang="en"><p>344022; 29 Nahichevansky Ave.; Rostov-on-Don</p></bio><email xlink:type="simple">xlma@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Савченко</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Savchenko</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Анастасия Викторовна Савченко, врач — акушер-гинеколог</p><p>344068; ул. Бодрая, д. 88/35; Ростов-на-Дону</p></bio><bio xml:lang="en"><p>344068; 88/35 Bodraya Str.; Rostov-on-Don</p></bio><email xlink:type="simple">savnas2014@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Слесарева</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Slesareva</surname><given-names>K. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кристина Витальевна Слесарева, к. м. н., врач — акушер-гинеколог</p><p>Научно-исследовательский институт акушерства и педиатрии; отделение гинекологии</p><p>344022; Нахичеванский пер., д. 29; Ростов-на-Дону</p></bio><bio xml:lang="en"><p>344022; 29 Nahichevansky Ave.; Rostov-on-Don</p></bio><email xlink:type="simple">slesareva.rniiap@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Ростовский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУ РО «Городская больница скорой медицинской помощи в г. Ростове-на-Дону»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Emergency Hospital in Rostov-on-Don</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>19</day><month>02</month><year>2025</year></pub-date><volume>22</volume><issue>5</issue><issue-title>ГИНЕКОЛОГИЯ</issue-title><fpage>89</fpage><lpage>94</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ермолова Н.В., Петров Ю.А., Левкович М.А., Савченко А.В., Слесарева К.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Ермолова Н.В., Петров Ю.А., Левкович М.А., Савченко А.В., Слесарева К.В.</copyright-holder><copyright-holder xml:lang="en">Ermolova N.V., Petrov Y.A., Levkovich M.A., Savchenko A.V., Slesareva K.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://docru.elpub.ru/jour/article/view/251">https://docru.elpub.ru/jour/article/view/251</self-uri><abstract><sec><title>   Цель обзора</title><p>   Цель обзора: провести анализ современных подходов к диагностике и лечению генитального эндометриоза.</p></sec><sec><title>   Основные положения</title><p>   Основные положения. Эндометриоз — это одно из самых распространенных гинекологических заболеваний, поражающее прежде всего женщин репродуктивного возраста, основные проявления которого — хроническая тазовая боль и бесплодие. Постоянная снижающая качество жизни тазовая боль приводит к тому, что пациентки находятся в состоянии длительного стресса, и у них возникают расстройства поведения. Согласно последним мировым рекомендациям, медикаментозное лечение — первая линия терапии эндометриоза, если беременность не является приоритетной задачей на данном этапе. Существует множество визуализационных методов диагностики этого заболевания, однако до сих пор продолжается поиск неинвазивных маркеров эндометриоза, позволяющих достоверно подтвердить диагноз.</p></sec><sec><title>   Заключение</title><p>   Заключение. Междисциплинарный подход и выбор адекватного лечения эндометриоза на каждом этапе жизни женщины могут ограничить ненужные хирургические вмешательства и лучше удовлетворять потребности пациенток.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>   Aim</title><p>   Aim: To analyze modern approaches to the diagnosis and treatment of genital endometriosis.</p></sec><sec><title>   Key points</title><p>   Key points. Endometriosis is one of the most common gynecological diseases, affecting mainly women of reproductive age, the main manifestations of which are chronic pelvic pain and infertility. Constant pelvic pain, which reduces the quality of life, leads to the fact that patients are in a state of prolonged stress, and they have behavioral disorders. According to the latest world recommendations, drug treatment is the first line of therapy for endometriosis, if pregnancy is not a priority at this stage. There are many imaging methods for diagnosing this disease, but the search for non-invasive markers of endometriosis that can reliably confirm the diagnosis is still ongoing.</p></sec><sec><title>   Conclusion</title><p>   Conclusion. An interdisciplinary approach and the choice of adequate treatment for endometriosis at each stage of a woman's life can limit unnecessary surgery and better meet the needs of patients.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>эндометриоз</kwd><kwd>аденомиоз</kwd><kwd>хроническая тазовая боль</kwd><kwd>прогестины</kwd><kwd>диеногест</kwd><kwd>маркеры эндометриоза</kwd></kwd-group><kwd-group xml:lang="en"><kwd>endometriosis</kwd><kwd>adenomyosis</kwd><kwd>chronic pelvic pain</kwd><kwd>progestins</kwd><kwd>dienogest</kwd><kwd>endometriosis markers</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Zondervan K.T., Becker C.M., Missmer S.A. Endometriosis. N. Engl. J. Med. 2020;382(13):1244–56. DOI: 10.1056/NEJMra1810764</mixed-citation><mixed-citation xml:lang="en">Zondervan K.T., Becker C.M., Missmer S.A. Endometriosis. N. Engl. J. Med. 2020;382(13):1244–56. DOI: 10.1056/NEJMra1810764</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Hill C.J., Fakhreldin M., Maclean A., Dobson L. et al. Endometriosis and fallopian tubes: theories of origin and clinical implications. J. Clin. Med. 2020;9(6):1905. DOI: 10.3390/jcm9061905</mixed-citation><mixed-citation xml:lang="en">Hill C.J., Fakhreldin M., Maclean A., Dobson L. et al. Endometriosis and fallopian tubes: theories of origin and clinical implications. J. Clin. Med. 2020;9(6):1905. DOI: 10.3390/jcm9061905</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Parazzini F., Esposito G., Tozzi L., Noli S. et al. Epidemiology of endometriosis and its comorbidities. Eur. J. Obstet. Gynecol. Reprod. Biol. 2017;209:3–7. DOI: 10.1016/j.ejogrb.2016.04.021</mixed-citation><mixed-citation xml:lang="en">Parazzini F., Esposito G., Tozzi L., Noli S. et al. Epidemiology of endometriosis and its comorbidities. Eur. J. Obstet. Gynecol. Reprod. Biol. 2017;209:3–7. DOI: 10.1016/j.ejogrb.2016.04.021</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Gambadauro P., Carli V., Hadlaczky G. Depressive symptoms among women with endometriosis : a systematic review and meta-analysis. Am. J. Obstet. Gynecol. 2019;220(3):230–41. DOI: 10.1016/j.ajog.2018.11.123</mixed-citation><mixed-citation xml:lang="en">Gambadauro P., Carli V., Hadlaczky G. Depressive symptoms among women with endometriosis : a systematic review and meta-analysis. Am. J. Obstet. Gynecol. 2019;220(3):230–41. DOI: 10.1016/j.ajog.2018.11.123</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">As-Sanie S., Black R., Giudice L.C., Gray Valbrun T. et al. Assessing research gaps and unmet needs in endometriosis. Am. J. Obstet. Gynecol. 2019;221(2):86–94. DOI: 10.1016/j.ajog.2019.02.033</mixed-citation><mixed-citation xml:lang="en">As-Sanie S., Black R., Giudice L.C., Gray Valbrun T. et al. Assessing research gaps and unmet needs in endometriosis. Am. J. Obstet. Gynecol. 2019;221(2):86–94. DOI: 10.1016/j.ajog.2019.02.033</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Škegro B., Bjedov S., Mikuš M., Mustač F. et al. Endometriosis, pain and mental health. Psychiatr. Danub. 2021;33(suppl.4):632–6.</mixed-citation><mixed-citation xml:lang="en">Škegro B., Bjedov S., Mikuš M., Mustač F. et al. Endometriosis, pain and mental health. Psychiatr. Danub. 2021;33(suppl.4):632–6.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Casalechi M., Vieira-Lopes M., Quessada M.P., Arão T.C. et al. Endometriosis and related pelvic pain: association with stress, anxiety and depressive symptoms. Minerva Obstet Gynecol. 2021;73(3):283–9. DOI: 10.23736/S2724-606X.21.04704-3</mixed-citation><mixed-citation xml:lang="en">Casalechi M., Vieira-Lopes M., Quessada M.P., Arão T.C. et al. Endometriosis and related pelvic pain: association with stress, anxiety and depressive symptoms. Minerva Obstet Gynecol. 2021;73(3):283–9. DOI: 10.23736/S2724-606X.21.04704-3</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Walker A.K., Kavelaars A., Heijnen C.J., Dantzer R. Neuroinflammation and comorbidity of pain and depression. Pharmacol. Rev. 2013;66(1):80–101. DOI: 10.1124/pr.113.008144</mixed-citation><mixed-citation xml:lang="en">Walker A.K., Kavelaars A., Heijnen C.J., Dantzer R. Neuroinflammation and comorbidity of pain and depression. Pharmacol. Rev. 2013;66(1):80–101. DOI: 10.1124/pr.113.008144</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Harsanyi S., Kupcova I., Danisovic L., Klein M. Selected biomarkers of depression: what are the effects of cytokines and inflammation? Int. J. Mol. Sci. 2022;24(1):578. DOI: 10.3390/ijms24010578</mixed-citation><mixed-citation xml:lang="en">Harsanyi S., Kupcova I., Danisovic L., Klein M. Selected biomarkers of depression: what are the effects of cytokines and inflammation? Int. J. Mol. Sci. 2022;24(1):578. DOI: 10.3390/ijms24010578</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Howren M.B., Lamkin D.M., Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom. Med. 2009;71(2):171–86. DOI: 10.1097/PSY.0b013e3181907c1b</mixed-citation><mixed-citation xml:lang="en">Howren M.B., Lamkin D.M., Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom. Med. 2009;71(2):171–86. DOI: 10.1097/PSY.0b013e3181907c1b</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Nabi M.Y., Nauhria S., Reel M., Londono S. et al. Endometriosis and irritable bowel syndrome: a systematic review and meta-analyses. Front. Med. (Lausanne). 2022;9:914356. DOI: 10.3389/fmed.2022.914356</mixed-citation><mixed-citation xml:lang="en">Nabi M.Y., Nauhria S., Reel M., Londono S. et al. Endometriosis and irritable bowel syndrome: a systematic review and meta-analyses. Front. Med. (Lausanne). 2022;9:914356. DOI: 10.3389/fmed.2022.914356</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Schomacker M.L., Hansen K.E., Ramlau-Hansen C.H., Forman A. Is endometriosis associated with irritable bowel syndrome? A cross-sectional study. Eur. J. Obstet. Gynecol. Reprod. Biol. 2018;231:65–9. DOI: 10.1016/j.ejogrb.2018.10.023</mixed-citation><mixed-citation xml:lang="en">Schomacker M.L., Hansen K.E., Ramlau-Hansen C.H., Forman A. Is endometriosis associated with irritable bowel syndrome? A cross-sectional study. Eur. J. Obstet. Gynecol. Reprod. Biol. 2018;231:65–9. DOI: 10.1016/j.ejogrb.2018.10.023</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Baker J.M., Al-Nakkash L., Herbst-Kralovetz M.M. Estrogen-gut microbiome axis: physiological and clinical implications. Maturitas. 2017;103:45–53. DOI: 10.1016/j.maturitas.2017.06.025</mixed-citation><mixed-citation xml:lang="en">Baker J.M., Al-Nakkash L., Herbst-Kralovetz M.M. Estrogen-gut microbiome axis: physiological and clinical implications. Maturitas. 2017;103:45–53. DOI: 10.1016/j.maturitas.2017.06.025</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Rowlands I.J., Hockey R., Abbott J.A., Montgomery G.W. et al. Body mass index and the diagnosis of endometriosis: findings from a national data linkage cohort study. Obes. Res. Clin. Pract. 2022;16(3):235–41. DOI: 10.1016/j.orcp.2022.04.002</mixed-citation><mixed-citation xml:lang="en">Rowlands I.J., Hockey R., Abbott J.A., Montgomery G.W. et al. Body mass index and the diagnosis of endometriosis: findings from a national data linkage cohort study. Obes. Res. Clin. Pract. 2022;16(3):235–41. DOI: 10.1016/j.orcp.2022.04.002</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Vercellini P., Eskenazi B., Consonni D., Somigliana E. et al. Oral contraceptives and risk of endometriosis : a systematic review and meta-analysis. Hum. Reprod. Update. 2011;17(2):159–70. DOI: 10.1093/humupd/dmq042</mixed-citation><mixed-citation xml:lang="en">Vercellini P., Eskenazi B., Consonni D., Somigliana E. et al. Oral contraceptives and risk of endometriosis : a systematic review and meta-analysis. Hum. Reprod. Update. 2011;17(2):159–70. DOI: 10.1093/humupd/dmq042</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Chapron C., Souza C., Borghese B., Lafay-Pillet M.C. et al. Oral contraceptives and endometriosis: the past use of oral contraceptives for treating severe primary dysmenorrhea is associated with endometriosis, especially deep infiltrating endometriosis. Hum. Reprod. 2011;26(8):2028–35. DOI: 10.1093/humrep/der156</mixed-citation><mixed-citation xml:lang="en">Chapron C., Souza C., Borghese B., Lafay-Pillet M.C. et al. Oral contraceptives and endometriosis: the past use of oral contraceptives for treating severe primary dysmenorrhea is associated with endometriosis, especially deep infiltrating endometriosis. Hum. Reprod. 2011;26(8):2028–35. DOI: 10.1093/humrep/der156</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Moura A.P.C., Ribeiro H.S.A.A., Bernardo W.M., Simões R. et al. Accuracy of transvaginal sonography versus magnetic resonance imaging in the diagnosis of rectosigmoid endometriosis : systematic review and meta-analysis [published correction appears in PLoS One. 2019;14(8):e0221499]. PLoS One. 2019;14(4):e0214842. DOI: 10.1371/journal.pone.0214842</mixed-citation><mixed-citation xml:lang="en">Moura A.P.C., Ribeiro H.S.A.A., Bernardo W.M., Simões R. et al. Accuracy of transvaginal sonography versus magnetic resonance imaging in the diagnosis of rectosigmoid endometriosis : systematic review and meta-analysis [published correction appears in PLoS One. 2019;14(8):e0221499]. PLoS One. 2019;14(4):e0214842. DOI: 10.1371/journal.pone.0214842</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Chowdary P., Stone K., Ma T., Readman E. et al. Multicentre retrospective study to assess diagnostic accuracy of ultrasound for superficial endometriosis — are we any closer? Aust. N. Z. J. Obstet. Gynaecol. 2019;59(2):279–84. DOI: 10.1111/ajo.12911</mixed-citation><mixed-citation xml:lang="en">Chowdary P., Stone K., Ma T., Readman E. et al. Multicentre retrospective study to assess diagnostic accuracy of ultrasound for superficial endometriosis — are we any closer? Aust. N. Z. J. Obstet. Gynaecol. 2019;59(2):279–84. DOI: 10.1111/ajo.12911</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Guo C., Zhang C. Platelet-to-lymphocyte ratio and CA125 level as a combined biomarker for diagnosing endometriosis and predicting pelvic adhesion severity. Front. Oncol. 2022;12:896152. DOI: 10.3389/fonc.2022.896152</mixed-citation><mixed-citation xml:lang="en">Guo C., Zhang C. Platelet-to-lymphocyte ratio and CA125 level as a combined biomarker for diagnosing endometriosis and predicting pelvic adhesion severity. Front. Oncol. 2022;12:896152. DOI: 10.3389/fonc.2022.896152</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Xue Y.H., You L.T., Ting H.F., Chen Y.W. et al. Increased risk of rheumatoid arthritis among patients with endometriosis: a nationwide population-based cohort study. Rheumatology (Oxford). 2021;60(7):3326–33. DOI: 10.1093/rheumatology/keaa784</mixed-citation><mixed-citation xml:lang="en">Xue Y.H., You L.T., Ting H.F., Chen Y.W. et al. Increased risk of rheumatoid arthritis among patients with endometriosis: a nationwide population-based cohort study. Rheumatology (Oxford). 2021;60(7):3326–33. DOI: 10.1093/rheumatology/keaa784</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Kusunoki M., Fujiwara Y., Komohara Y., Imamura Y. et al. Hemoglobin-induced continuous activation of macrophages in endometriotic cysts: a potential mechanism of endometriosis development and carcinogenesis. Med. Mol. Morphol. 2021;54(2):122–32. DOI: 10.1007/s00795-020-00272-4</mixed-citation><mixed-citation xml:lang="en">Kusunoki M., Fujiwara Y., Komohara Y., Imamura Y. et al. Hemoglobin-induced continuous activation of macrophages in endometriotic cysts: a potential mechanism of endometriosis development and carcinogenesis. Med. Mol. Morphol. 2021;54(2):122–32. DOI: 10.1007/s00795-020-00272-4</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Chapron C., Marcellin L., Borghese B., Santulli P. Rethinking mechanisms, diagnosis and management of endometriosis. Nat. Rev. Endocrinol. 2019;15(11):666–82. DOI: 10.1038/s41574-019-0245-z</mixed-citation><mixed-citation xml:lang="en">Chapron C., Marcellin L., Borghese B., Santulli P. Rethinking mechanisms, diagnosis and management of endometriosis. Nat. Rev. Endocrinol. 2019;15(11):666–82. DOI: 10.1038/s41574-019-0245-z</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Kitajima M., Khan K.N., Harada A., Taniguchi K. et al. Association between ovarian endometrioma and ovarian reserve. Front. Biosci. (Elite Ed). 2018;10(1):92–102. DOI: 10.2741/e810</mixed-citation><mixed-citation xml:lang="en">Kitajima M., Khan K.N., Harada A., Taniguchi K. et al. Association between ovarian endometrioma and ovarian reserve. Front. Biosci. (Elite Ed). 2018;10(1):92–102. DOI: 10.2741/e810</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Muzii L., Galati G., Di Tucci C., Di Feliciantonio M. et al. Medical treatment of ovarian endometriomas: a prospective evaluation of the effect of dienogest on ovarian reserve, cyst diameter, and associated pain. Gynecol. Endocrinol. 2020;36(1):81–3. DOI: 10.1080/09513590.2019.1640199</mixed-citation><mixed-citation xml:lang="en">Muzii L., Galati G., Di Tucci C., Di Feliciantonio M. et al. Medical treatment of ovarian endometriomas: a prospective evaluation of the effect of dienogest on ovarian reserve, cyst diameter, and associated pain. Gynecol. Endocrinol. 2020;36(1):81–3. DOI: 10.1080/09513590.2019.1640199</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Králíčková M., Laganà A.S., Ghezzi F., Vetvicka V. Endometriosis and risk of ovarian cancer: what do we know? Arch. Gynecol. Obstet. 2020;301(1):1–10. DOI: 10.1007/s00404-019-05358-8</mixed-citation><mixed-citation xml:lang="en">Králíčková M., Laganà A.S., Ghezzi F., Vetvicka V. Endometriosis and risk of ovarian cancer: what do we know? Arch. Gynecol. Obstet. 2020;301(1):1–10. DOI: 10.1007/s00404-019-05358-8</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Pejovic T., Thisted S., White M., Nezhat F.R. Endometriosis and endometriosis-associated ovarian cancer (EAOC). Adv. Exp. Med. Biol. 2020;1242:73–87. DOI: 10.1007/978-3-030-38474-6_5</mixed-citation><mixed-citation xml:lang="en">Pejovic T., Thisted S., White M., Nezhat F.R. Endometriosis and endometriosis-associated ovarian cancer (EAOC). Adv. Exp. Med. Biol. 2020;1242:73–87. DOI: 10.1007/978-3-030-38474-6_5</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Khan K.N., Fujishita A., Koshiba A., Kuroboshi H. et al. Biological differences between intrinsic and extrinsic adenomyosis with coexisting deep infiltrating endometriosis. Reprod. Biomed. Online. 2019;39(2):343–53. DOI: 10.1016/j.rbmo.2019.03.210</mixed-citation><mixed-citation xml:lang="en">Khan K.N., Fujishita A., Koshiba A., Kuroboshi H. et al. Biological differences between intrinsic and extrinsic adenomyosis with coexisting deep infiltrating endometriosis. Reprod. Biomed. Online. 2019;39(2):343–53. DOI: 10.1016/j.rbmo.2019.03.210</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Chapron C., Vannuccini S., Santulli P., Abrão M.S. et al. Diagnosing adenomyosis: an integrated clinical and imaging approach. Hum. Reprod. Update. 2020;26(3):392–411. DOI: 10.1093/humupd/dmz049</mixed-citation><mixed-citation xml:lang="en">Chapron C., Vannuccini S., Santulli P., Abrão M.S. et al. Diagnosing adenomyosis: an integrated clinical and imaging approach. Hum. Reprod. Update. 2020;26(3):392–411. DOI: 10.1093/humupd/dmz049</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Tellum T., Nygaard S., Lieng M. Noninvasive diagnosis of adenomyosis : a structured review and meta-analysis of diagnostic accuracy in imaging. J. Minim. Invasive Gynecol. 2020;27(2):408–18.e3. DOI: 10.1016/j.jmig.2019.11.001</mixed-citation><mixed-citation xml:lang="en">Tellum T., Nygaard S., Lieng M. Noninvasive diagnosis of adenomyosis : a structured review and meta-analysis of diagnostic accuracy in imaging. J. Minim. Invasive Gynecol. 2020;27(2):408–18.e3. DOI: 10.1016/j.jmig.2019.11.001</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Saraswat L., Ayansina D., Cooper K.G., Bhattacharya S. et al. Impact of endometriosis on risk of further gynaecological surgery and cancer: a national cohort study. BJOG. 2018;125(1):64–72. DOI: 10.1111/1471-0528.14793</mixed-citation><mixed-citation xml:lang="en">Saraswat L., Ayansina D., Cooper K.G., Bhattacharya S. et al. Impact of endometriosis on risk of further gynaecological surgery and cancer: a national cohort study. BJOG. 2018;125(1):64–72. DOI: 10.1111/1471-0528.14793</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Edi R., Cheng T. Endometriosis: evaluation and treatment. Am. Fam. Physician. 2022;106(4):397–404.</mixed-citation><mixed-citation xml:lang="en">Edi R., Cheng T. Endometriosis: evaluation and treatment. Am. Fam. Physician. 2022;106(4):397–404.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Vercellini P., Buggio L., Frattaruolo M.P., Borghi A. et al. Medical treatment of endometriosis-related pain. Best Pract. Res. Clin. Obstet. Gynaecol. 2018;51:68–91. DOI: 10.1016/j.bpobgyn.2018.01.015</mixed-citation><mixed-citation xml:lang="en">Vercellini P., Buggio L., Frattaruolo M.P., Borghi A. et al. Medical treatment of endometriosis-related pain. Best Pract. Res. Clin. Obstet. Gynaecol. 2018;51:68–91. DOI: 10.1016/j.bpobgyn.2018.01.015</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Piacenti I., Viscardi M.F., Masciullo L., Sangiuliano C. et al. Dienogest versus continuous oral levonorgestrel/EE in patients with endometriosis: what's the best choice? Gynecol. Endocrinol. 2021;37(5):471–5. DOI: 10.1080/09513590.2021.1892632</mixed-citation><mixed-citation xml:lang="en">Piacenti I., Viscardi M.F., Masciullo L., Sangiuliano C. et al. Dienogest versus continuous oral levonorgestrel/EE in patients with endometriosis: what's the best choice? Gynecol. Endocrinol. 2021;37(5):471–5. DOI: 10.1080/09513590.2021.1892632</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Casper R.F. Progestin-only pills may be a better first-line treatment for endometriosis than combined estrogen-progestin contraceptive pills. Fertil. Steril. 2017;107(3):533–6. DOI: 10.1016/j.fertnstert.2017.01.003</mixed-citation><mixed-citation xml:lang="en">Casper R.F. Progestin-only pills may be a better first-line treatment for endometriosis than combined estrogen-progestin contraceptive pills. Fertil. Steril. 2017;107(3):533–6. DOI: 10.1016/j.fertnstert.2017.01.003</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Murji A., Biberoğlu K., Leng J., Mueller M.D. et al. Use of dienogest in endometriosis : a narrative literature review and expert commentary. Curr. Med. Res. Opin. 2020;36(5):895–907. DOI: 10.1080/03007995.2020.1744120</mixed-citation><mixed-citation xml:lang="en">Murji A., Biberoğlu K., Leng J., Mueller M.D. et al. Use of dienogest in endometriosis : a narrative literature review and expert commentary. Curr. Med. Res. Opin. 2020;36(5):895–907. DOI: 10.1080/03007995.2020.1744120</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Hughes G.C., Choubey D. Modulation of autoimmune rheumatic diseases by oestrogen and progesterone. Nat. Rev. Rheumatol. 2014;10(12):740–51. DOI: 10.1038/nrrheum.2014.144</mixed-citation><mixed-citation xml:lang="en">Hughes G.C., Choubey D. Modulation of autoimmune rheumatic diseases by oestrogen and progesterone. Nat. Rev. Rheumatol. 2014;10(12):740–51. DOI: 10.1038/nrrheum.2014.144</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Collins M.K., McCutcheon C.R., Petroff M.G. Impact of estrogen and progesterone on immune cells and host-pathogen interactions in the lower female reproductive tract. J. Immunol. 2022;209(8):1437–49. DOI: 10.4049/jimmunol.2200454</mixed-citation><mixed-citation xml:lang="en">Collins M.K., McCutcheon C.R., Petroff M.G. Impact of estrogen and progesterone on immune cells and host-pathogen interactions in the lower female reproductive tract. J. Immunol. 2022;209(8):1437–49. DOI: 10.4049/jimmunol.2200454</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Moulton V.R. Sex hormones in acquired immunity and autoimmune disease. Front. Immunol. 2018;9:2279. DOI: 10.3389/fimmu.2018.02279</mixed-citation><mixed-citation xml:lang="en">Moulton V.R. Sex hormones in acquired immunity and autoimmune disease. Front. Immunol. 2018;9:2279. DOI: 10.3389/fimmu.2018.02279</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Liu Y., Wang J., Zhang X. An update on the multifaceted role of NF-kappa B in endometriosis. Int. J. Biol. Sci. 2022;18(11):4400–13. DOI: 10.7150/ijbs.72707</mixed-citation><mixed-citation xml:lang="en">Liu Y., Wang J., Zhang X. An update on the multifaceted role of NF-kappa B in endometriosis. Int. J. Biol. Sci. 2022;18(11):4400–13. DOI: 10.7150/ijbs.72707</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Mita S., Shimizu Y., Notsu T., Imada K. et al. Dienogest inhibits Toll-like receptor 4 expression induced by costimulation of lipopolysaccharide and high-mobility group box 1 in endometrial epithelial cells. Fertil. Steril. 2011;96(6):1485–9.e4. DOI: 10.1016/j.fertnstert.2011.09.040</mixed-citation><mixed-citation xml:lang="en">Mita S., Shimizu Y., Notsu T., Imada K. et al. Dienogest inhibits Toll-like receptor 4 expression induced by costimulation of lipopolysaccharide and high-mobility group box 1 in endometrial epithelial cells. Fertil. Steril. 2011;96(6):1485–9.e4. DOI: 10.1016/j.fertnstert.2011.09.040</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Arosh J.A., Sivakumar K.K., Lee J., Banu S.K. Effects of selective inhibition of prostaglandin E2 receptors EP2 and EP4 on the miRNA profile in endometriosis. Mol. Cell Endocrinol. 2022;558:111728. DOI: 10.1016/j.mce.2022.111728</mixed-citation><mixed-citation xml:lang="en">Arosh J.A., Sivakumar K.K., Lee J., Banu S.K. Effects of selective inhibition of prostaglandin E2 receptors EP2 and EP4 on the miRNA profile in endometriosis. Mol. Cell Endocrinol. 2022;558:111728. DOI: 10.1016/j.mce.2022.111728</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Koshiba A., Mori T., Okimura H., Akiyama K. et al. Dienogest therapy during the early stages of recurrence of endometrioma might be an alternative therapeutic option to avoid repeat surgeries. J. Obstet. Gynaecol. Res. 2018;44(10):1970–6. DOI: 10.1111/jog.13725</mixed-citation><mixed-citation xml:lang="en">Koshiba A., Mori T., Okimura H., Akiyama K. et al. Dienogest therapy during the early stages of recurrence of endometrioma might be an alternative therapeutic option to avoid repeat surgeries. J. Obstet. Gynaecol. Res. 2018;44(10):1970–6. DOI: 10.1111/jog.13725</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Lee J.H., Song J.Y., Yi K.W., Lee S.R. et al. Effectiveness of dienogest for treatment of recurrent endometriosis: multicenter data. Reprod. Sci. 2018;25(10):1515–22. DOI: 10.1177/1933719118779733</mixed-citation><mixed-citation xml:lang="en">Lee J.H., Song J.Y., Yi K.W., Lee S.R. et al. Effectiveness of dienogest for treatment of recurrent endometriosis: multicenter data. Reprod. Sci. 2018;25(10):1515–22. DOI: 10.1177/1933719118779733</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Vignali M., Belloni G.M., Pietropaolo G., Barbasetti Di Prun A. et al. Effect of dienogest therapy on the size of the endometrioma. Gynecol. Endocrinol. 2020;36(8):723–7. DOI: 10.1080/09513590.2020.1725965</mixed-citation><mixed-citation xml:lang="en">Vignali M., Belloni G.M., Pietropaolo G., Barbasetti Di Prun A. et al. Effect of dienogest therapy on the size of the endometrioma. Gynecol. Endocrinol. 2020;36(8):723–7. DOI: 10.1080/09513590.2020.1725965</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Del Pup L., Berretta M. As dienogest effectively suppress could it also reduce endometriosis associated ovarian cancers? A further motivation for long-term medical treatment. World Cancer Res. J. 2015;2(2):e526.</mixed-citation><mixed-citation xml:lang="en">Del Pup L., Berretta M. As dienogest effectively suppress could it also reduce endometriosis associated ovarian cancers? A further motivation for long-term medical treatment. World Cancer Res. J. 2015;2(2):e526.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Vannuccini S., Luisi S., Tosti C., Sorbi F. et al. Role of medical therapy in the management of uterine adenomyosis. Fertil. Steril. 2018;109(3):398–405. DOI: 10.1016/j.fertnstert.2018.01.013</mixed-citation><mixed-citation xml:lang="en">Vannuccini S., Luisi S., Tosti C., Sorbi F. et al. Role of medical therapy in the management of uterine adenomyosis. Fertil. Steril. 2018;109(3):398–405. DOI: 10.1016/j.fertnstert.2018.01.013</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Ota I., Taniguchi F., Ota Y., Nagata H. et al. A controlled clinical trial comparing potentprogestins, LNG-IUS and dienogest, for the treatment of women with adenomyosis. Reprod. Med. Biol. 2021;20(4):427–34. DOI: 10.1002/rmb2.12408</mixed-citation><mixed-citation xml:lang="en">Ota I., Taniguchi F., Ota Y., Nagata H. et al. A controlled clinical trial comparing potentprogestins, LNG-IUS and dienogest, for the treatment of women with adenomyosis. Reprod. Med. Biol. 2021;20(4):427–34. DOI: 10.1002/rmb2.12408</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Yang S., Liu Y., Wen J., Sun Y. et al. Clinical efficacy of dienogest versus levonorgestrel-releasing intrauterine system for adenomyosis. Evid. Based Complement Alternat. Med. 2022;2022:1995472. DOI: 10.1155/2022/1995472</mixed-citation><mixed-citation xml:lang="en">Yang S., Liu Y., Wen J., Sun Y. et al. Clinical efficacy of dienogest versus levonorgestrel-releasing intrauterine system for adenomyosis. Evid. Based Complement Alternat. Med. 2022;2022:1995472. DOI: 10.1155/2022/1995472</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Green I.C., Burnett T., Famuyide A. Persistent pelvic pain in patients with endometriosis. Clin. Obstet. Gynecol. 2022;65(4):775–85. DOI: 10.1097/GRF.0000000000000712</mixed-citation><mixed-citation xml:lang="en">Green I.C., Burnett T., Famuyide A. Persistent pelvic pain in patients with endometriosis. Clin. Obstet. Gynecol. 2022;65(4):775–85. DOI: 10.1097/GRF.0000000000000712</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
