docruДоктор.РуTitle1727-23782713-2994ООО "ГК "РУСМЕДИКАЛ"10.31550/1727-2378-2023-22-1-62-67docru-208Research ArticleАКУШЕРСТВО И ПЕРИНАТОЛОГИЯOBSTETRICS AND PERINATOLOGYОсобенности метаболизма у женщин с преэклампсией, сочетающейся с гестационным сахарным диабетомFeatures of Metabolism in Women with Preeclampsia Combined with Gestational Diabetes Mellitushttps://orcid.org/0000-0002-4585-4646АникеевА. С.AnikeevA. S.

Аникеев Андрей Сергеевич — аспирант кафедры акушерства, гинекологии и репродуктивной медицины Медицинского института

117198, г. Москва, ул. Миклухо-Маклая, д. 6

6 Miklouho-Maclay Str., Moscow, 117198

keshafike@gmail.comhttps://orcid.org/0000-0001-5795-2393СтарцеваН. М.StartsevaN. M.

Старцева Надежда Михайловна — д. м. н., профессор кафедры акушерства, гинекологии и репродуктивной медицины Медицинского института

117198, г. Москва, ул. Миклухо-Маклая, д. 6

6 Miklouho-Maclay Str., Moscow, 117198

n.startseva@yahoo.comhttps://orcid.org/0000-0002-7048-4827ГрабовскийВ. М.GrabovskyV. M.

Грабовский Василий Михайлович — врач акушер-гинеколог

123182, г. Москва, Пехотная ул., д. 3

3 Pekhotnaya Str., Moscow, 123182

grabowsky@mail.ruhttps://orcid.org/0000-0001-5882-9995ОрдиянцИ. М.OrdiyantsI. M.

Ордиянц Ирина Михайловна — профессор кафедры акушерства, гинекологии и репродуктивной медицины Медицинского института

117198, г. Москва, ул. Миклухо-Маклая, д. 6

6 Miklouho-Maclay Str., Moscow, 117198

ordiyantc@mail.ruГазарянЛ. Г.GazaryanL. G.

Газарян Лусине Гавриловна — аспирант кафедры акушерства, гинекологии и репродуктивной медицины Медицинского института

117198, г. Москва, ул. Миклухо-Маклая, д. 6

6 Miklouho-Maclay Str., Moscow, 117198

gazaryanlusine007.lg@gmail.comhttps://orcid.org/0000-0002-6681-9807Ivanovaam@gmail.comА. М.SavichevaA. M.

Савичева Анна Михайловна — врач акушер-гинеколог родильного дома

105094, г. Москва, Госпитальная пл., д. 2

2 Hospital Square, Moscow, 105094

ФГАОУ ВО «Российский университет дружбы народов»РоссияPeoples’ Friendship University of RussiaRussian FederationГБУЗ «Городская клиническая больница № 52 Департамента здравоохранения города Москвы»РоссияMunicipal Clinical Hospital No. 52 of the Moscow Department of HealthRussian FederationГБУЗ «Городская клиническая больница № 29 имени Н.Э. Баумана»РоссияMunicipal Clinical Hospital No. 29 n.a. N.E. Bauman of the Moscow Department of HealthRussian Federation202318022025221ГИНЕКОЛОГИЯ6267Copyright © Аникеев А.С., Старцева Н.М., Грабовский В.М., Ордиянц И.М., Газарян Л.Г., ivanovaam@gmail.com А.М., 20252025Аникеев А.С., Старцева Н.М., Грабовский В.М., Ордиянц И.М., Газарян Л.Г., ivanovaam@gmail.com А.М.Anikeev A.S., Startseva N.M., Grabovsky V.M., Ordiyants I.M., Gazaryan L.G., Savicheva A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://docru.elpub.ru/jour/article/view/208Цель обзора

Цель обзора: обобщить доказанные прогностические и диагностические критерии гестационных осложнений, обусловленных сочетанием гестационного сахарного диабета (ГСД) и преэклампсии (ПЭ).

Основные положения

Основные положения. Приведен аналитический обзор современной парадигмы ГСД и ПЭ, их осложнений, а также перинатальных и отдаленных исходов для матери и ребенка. Систематизированы данные о клинико-анамнестических и лабораторных факторах риска ПЭ при ГСД. Описана тесная взаимосвязь механизмов развития ПЭ и ГСД — ангиогенного дисбаланса и метаболических нарушений в плаценте.

Заключение

Заключение. ГСД признан независимым фактором риска развития ПЭ, причем этот риск тем больше, чем менее ГСД компенсирован. Синдром поликистозных яичников и повышенный индекс массы тела в качестве сопутствующих факторов нарушения метаболизма также увеличивают риск развития ПЭ. Предполагаемая патогенетическая общность ГСД и ПЭ заключается в наличии окислительного стресса и метавоспаления, усиливающих инсулинорезистентность и вызывающих эндотелиальную дисфункцию.

Objective of the Review

Objective of the Review: To summarize the proven prognostic and diagnostic criteria for gestational complications caused by a combination of gestational diabetes mellitus (GDM) and preeclampsia (PE).

Key points

Key points. There is an analytical review of the modern paradigm of GDM and PE, their complications, as well as perinatal and long-term outcomes for mother and child. The data on clinical, anamnestic and laboratory risk factors of PE in GDM are systematized. A close relationship between the mechanisms of PE and GDM development — angiogenic imbalance and metabolic disorders in the placenta is described.

Conclusion

Conclusion. GDM is recognized as an independent risk factor for the development of PE, and this risk is the greater the less GDM is compensated. Polycystic ovary syndrome and an increased body mass index as concomitant factors of metabolic disorders also increase the risk of developing PE. The supposed pathogenetic commonality of GDM and PE is the presence of oxidative stress and metaflammation, which increase insulin resistance and cause endothelial dysfunction.

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The authors declare that there are no conflicts of interest present.