docruДоктор.РуTitle1727-23782713-2994ООО "ГК "РУСМЕДИКАЛ"10.31550/1727-2378-2023-22-5-62-68docru-202Research ArticleГИНЕКОЛОГИЯGYNECOLOGYПотенциал транс-ресвератрола в коррекции менопаузальных расстройств и возраст-ассоциированных заболеванийPotential of Trans-Resveratrol in the Prevention of Menopausal Disorders and Age-Associated Morbidityhttps://orcid.org/0000-0002-9916-6128КозловП. В.KozlovP. V.

Павел Васильевич Козлов, д. м. н., профессор

лечебный факультет; кафедра акушерства и гинекологии

117997; ул. Островитянова, д. 1; Москва

117997; 1 Ostrovityanova Str.; Moscow

drkpv@mail.ruФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Министерства здравоохранения Российской ФедерацииРоссияPirogov Russian National Research Medical UniversityRussian Federation202318022025225ГИНЕКОЛОГИЯ6268Copyright © Козлов П.В., 20252025Козлов П.В.Kozlov P.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://docru.elpub.ru/jour/article/view/202   Цель обзора

   Цель обзора: поиск альтернативных путей профилактики возраст-ассоциированной патологии у женщин, обусловленной в том числе прогрессирующим снижением уровня эстрогенов в период менопаузального перехода и постменопаузы.

   Основные положения

   Основные положения. При наличии противопоказаний к назначению менопаузальной гормональной терапии или на этапе обследования выбор альтернативных способов коррекции климактерических расстройств и системных метаболических нарушений должен соответствовать высокому профилю безопасности и эффективности. В обзоре подробно описаны фармакологические эффекты фитоэстрогена ресвератрола, механизмы реализации эстрогеноподобного, антипролиферативного, противовоспалительного и антиоксидантногодействия и возможности клинического применения в виде пищевых добавок.

   Заключение

   Заключение. Назначение фитоэстрогена транс-ресвератрола у женщин в пери- и постменопаузе является альтернативным подходом в снижении выраженности менопаузальных расстройств и профилактики системных метаболических нарушений. Обладая высокой биодоступностью в транс-изомерной форме и высоким профилем безопасности, он является оптимальным негормональным средством коррекции менопаузальных симптомов, торможения некоторых процессов старения, а также имеет значимый потенциал предотвращения возраст-ассоциированных заболеваний, что позволяет существенно улучшить качество жизни женщины в период менопаузы.

   Aim

   Aim: to investigate alternative option to prevent age-associated pathology in women, caused, by progressive decrease of estrogen level during the menopausal transition period.

   Key points

   Key points. If there are contraindications to the menopausal hormone therapy or at the examination stage, the choice of alternative methods for prevention and treatment of menopausal symptoms and systemic metabolic disorders should correspond to a high safety and efficacy profile. This review describes in detail the pharmacological effects of the phytoestrogen resveratrol, the mechanisms of the implementation of estrogen-like, antiproliferative, anti-inflammatory and antioxidant effects and the possibility of clinical use in the form of dietary supplements.

   Conclusion

   Conclusion. The prescription of the phytoestrogen trans-resveratrol is an alternative approach to the relief of menopausal disorders and the prevention of systemic metabolic disorders. Possessing as high bio-active and optimal safe alternative due to trans-isomer form, it is the optimal non-hormonal remedy for correcting menopausal symptoms, inhibiting some aging processes, and also has a significant potential for preventing age-related diseases.

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The authors declare that there are no conflicts of interest present.