docruДоктор.РуTitle1727-23782713-2994ООО "ГК "РУСМЕДИКАЛ"10.31550/1727-2378-2023-22-1-11-15docru-151Research ArticleГИНЕКОЛОГИЯGYNECOLOGYMetabesity у женщин: долгосрочные последствия для здоровьяMetabesity in Women: Long-term Health Effectshttps://orcid.org/0000-0002-5342-8129ОразовМ. Р.OrazovM. R.

Оразов Мекан Рахимбердыевич — д. м. н., профессор кафедры акушерства, гинекологии и репродуктивной медицины Медицинского института

117198, г. Москва, ул. Миклухо-Маклая, д. 6

6 Miklouho-Maclay Str., Moscow, 117198

omekan@mail.ruhttps://orcid.org/0000-0003-1101-4419РадзинскийВ. Е.RadzinskyV. E.

Радзинский Виктор Евсеевич — член-корреспондент РАН, д. м. н., профессор, заведующий кафедрой акушерства, гинекологии и репродуктивной медицины Медицинского института

117198, г. Москва, ул. Миклухо-Маклая, д. 6

6 Miklouho-Maclay Str., Moscow, 117198

radzinsky@mail.ruhttps://orcid.org/0000-0003-1940-4534ХамошинаМ. Б.KhamoshinaM. B.

Хамошина Марина Борисовна — профессор кафедры акушерства, гинекологии и репродуктивной медицины Медицинского института

117198, г. Москва, ул. Миклухо-Маклая, д. 6

6 Miklouho-Maclay Str., Moscow, 117198

khamoshina@mail.ruhttps://orcid.org/0000-0002-5773-6399МуллинаИ. А.MullinaI. A.

Муллина Ирина Александровна — аспирант кафедры акушерства, гинекологии и репродуктивной медицины Медицинского института

 117198, г. Москва, ул. Миклухо-Маклая, д. 6

6 Miklouho-Maclay Str., Moscow, 117198

211irina2111@rambler.ruhttps://orcid.org/0000-0003-2116-1420АртеменкоЮ. С.ArtemenkoYu. S.

Артеменко Юлия Сергеевна — аспирант кафедры акушерства, гинекологии и репродуктивной медицины Медицинского института

117198, г. Москва, ул. Миклухо-Маклая, д. 6

6 Miklouho-Maclay Str., Moscow, 117198

iu.pavlova@yandex.ruhttps://orcid.org/0000-0003-4292-6728РябоваВ. А.RyabovaV. A.

Рябова Валентина Андреевна — ассистент кафедры акушерства, гинекологии и репродуктивной медицины Медицинского института

117198, г. Москва, ул. Миклухо-Маклая, д. 6

6 Miklouho-Maclay Str., Moscow, 117198

mikhe-valentina@yandex.ruФГАОУ ВО «Российский университет дружбы народов»РоссияPeoples’ Friendship University of RussiaRussian Federation202317022025221ГИНЕКОЛОГИЯ1115Copyright © Оразов М.Р., Радзинский В.Е., Хамошина М.Б., Муллина И.А., Артеменко Ю.С., Рябова В.А., 20252025Оразов М.Р., Радзинский В.Е., Хамошина М.Б., Муллина И.А., Артеменко Ю.С., Рябова В.А.Orazov M.R., Radzinsky V.E., Khamoshina M.B., Mullina I.A., Artemenko Y.S., Ryabova V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://docru.elpub.ru/jour/article/view/151Цель обзора

Цель обзора: представить имеющиеся в современной литературе данные о влиянии ожирения на здоровье и качество жизни женщины.

Основные положения

Основные положения. Термин metabecity подразумевает спектр состояний, ассоциированных с ожирением и его последствиями. Патогенетически его относят к метаболическим аберрациям, связанным с ожирением: вялотекущее воспаление, митохондриальная дисфункция и изменения микробиома кишечника. Наряду с генетической составляющей, фенотипы metabecity во многом являются результатом малоподвижного образа жизни и нездорового питания. Metabecity связано с целым рядом сопутствующих заболеваний, угрожающих не только здоровью, но и жизни, включая артериальную гипертензию, сердечную недостаточность, инфаркт миокарда и инсульт. Инсулинорезистентность, гипертоническая болезнь, прогрессирующий атеросклероз, дислипидемия и жировой гепатоз у лиц с ожирением встречаются значимо чаще, чем в популяции. В представленном литературном обзоре резюмированы современные представления о влиянии metabecity на здоровье женщины в долгосрочной перспективе.

Заключение

Заключение. В последние годы растет интерес к прогнозированию и профилактике заболеваний, предопределяющих качество и продолжительность жизни. С учетом закономерных изменений гендерной составляющей населения с возрастом особый интерес представляет влияние ожирения и его последствий на здоровье женщин всех возрастных категорий. Ожирение увеличивает риск и общую смертность от рака. Metabesity отрицательно влияет на гормональный гомеостаз в женском организме и повышает риск дегенеративных состояний, в том числе деменции. С учетом генетической составляющей стратегии борьбы с мetabesity, включая нивелирование влияния малоподвижного образа жизни и нерационального питания, следует реализовать начиная с раннего детства. Модификация образа жизни — единственный доказанный способ лечить/профилактировать metabesity и связанные/обусловленные им болезни.

Objective of the Review

Objective of the Review: To present the available data on the impact of obesity on woman’s health and quality of life.

Key Points

Key Points. The term “metabesity” includes a range of conditions associated with obesity and its sequelae. From pathogenic point of view, it is an obesity-associated metabolic aberration: subacute inflammation, mitochondrial dysfunction, and changed gut microbiome. Together with a genetic component, the phenotypes of metabesity are mostly a result of sedentary lifestyle and unhealthy eating. Metabesity is associated with a number of both health- and life-threatening comorbidities, including arterial hypertension, cardiac failure, myocardial infraction, and stroke. Insulin resistance, hypertensive disease, advanced arteriosclerosis, dyslipidemia and fatty hepatosis are more frequent in obese people than in the general population. This literature overview presents a modern idea of the metabesity impact on the long-term health of a woman.

Conclusion

Conclusion. Recently, forecasting and prevention of diseases affecting the quality and duration of life have been attracting more and more interest. Taking into account the regular changes in the gender component of the population with age, obesity and its impact on the health of women from various age categories are of special interest. Obesity increases the risk and overall cancer mortality. Metabesity affects hormonal homoeostasis in the female body and increases the risk of degenerative conditions, including dementia. Taking into account the genetic component, the strategies to tackle metabesity, including a campaign against sedentary lifestyle and unhealthy eating, should be initiated since early childhood. Lifestyle modification is the only proven way to manage/prevent metabesity and associated diseases.

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The authors declare that there are no conflicts of interest present.