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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">docru</journal-id><journal-title-group><journal-title xml:lang="ru">Доктор.Ру</journal-title><trans-title-group xml:lang="en"><trans-title>Title</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1727-2378</issn><issn pub-type="epub">2713-2994</issn><publisher><publisher-name>ООО "ГК "РУСМЕДИКАЛ"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31550/1727-2378-2023-22-7-7-12</article-id><article-id custom-type="elpub" pub-id-type="custom">docru-143</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГАСТРОЭНТЕРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GASTROENTEROLOGY</subject></subj-group></article-categories><title-group><article-title>Эозинофильные заболевания желудочно-кишечного  тракта. Эозинофильный энтерит у детей</article-title><trans-title-group xml:lang="en"><trans-title>Eosinophilic Gastrointestinal Diseases.  Eosinophilic Enteritis in Children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2847-6268</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бережная</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Berezhnaya</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бережная Ирина Владимировна  — к. м. н., доцент кафедры педиатрии имени академика Г.Н. Сперанского;  врач-педиатр </p><p>125993,  г. Москва, ул. Баррикадная, д. 2/1, стр. 1</p></bio><bio xml:lang="en"><p>2/1 Barrikadnaya Str., build. 1, Moscow</p><p>28 Geroev Panfilovtsev Str., Moscow,  125373</p><p> </p></bio><email xlink:type="simple">berezhnaya-irina26@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4200-4598</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Захарова</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Zakharova</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Захарова Ирина Николаевна— д. м. н., профессор, заведующая кафедрой педиатрии имени академика Г.Н. Сперанского </p><p>125993,  г. Москва, ул. Баррикадная, д. 2/1, стр. 1</p></bio><bio xml:lang="en"><p>2/1 Barrikadnaya Str., build. 1, Moscow,  125993</p></bio><email xlink:type="simple">zakharova-rmapo@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3181-9601</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Османов</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Osmanov</surname><given-names>I. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Османов Исмаил Магомедович — д. м. н., профессор, главный врач</p><p> 125373, г. Москва, ул. Героев Панфиловцев, д. 28</p></bio><bio xml:lang="en"><p>28 Geroev Panfilovtsev Str., Moscow,  125373</p></bio><email xlink:type="simple">osmanovim@zdrav.mos.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скоробогатова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Skorobogatova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Скоробогатова Екатерина Владимировна — к. м. н., заведующая гастроэнтерологическим отделением</p><p> 125373,  г. Москва, ул. Героев Панфиловцев, д. 28</p></bio><bio xml:lang="en"><p> 28 Geroev Panfilovtsev Str., Moscow, 125373</p></bio><email xlink:type="simple">katrinscor@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гончарова</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Goncharova</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гончарова Людмила Викторовна  — врач-педиатр педиатрического отделения</p><p> 125373,  г. Москва, ул. Героев Панфиловцев, д. 28</p></bio><bio xml:lang="en"><p>28 Geroev Panfilovtsev Str., Moscow, 125373</p></bio><email xlink:type="simple">doct-goncharova@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дмитриева</surname><given-names>Д. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Dmitrieva</surname><given-names>D. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дмитриева Диана Кирилловна — аспирант кафедры педиатрии имени академика Г.Н. Сперанского </p><p>125993,  г. Москва, ул. Баррикадная, д. 2/1, стр. 1</p></bio><bio xml:lang="en"><p> 2/1 Barrikadnaya Str., build. 1, Moscow,  125993</p></bio><email xlink:type="simple">dmitrievadi@mail.ru</email><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации;  ГБУЗ «Детская городская клиническая больница имени З.А. Башляевой Департамента здравоохранения города Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education;  Z.A. Bashlyaeva Municipal Clinical Children’s Hospital at Moscow Healthcare Department</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГБУЗ «ДГКБ им. З.А. Башляевой ДЗМ»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Z.A. Bashlyaeva Municipal Clinical Children’s Hospital at Moscow Healthcare Department</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ГБУЗ «ДГКБ им. З.А. Башляевой ДЗМ».</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Z.A. Bashlyaeva Municipal Clinical Children’s Hospital at Moscow Healthcare Department</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ФГБОУ ДПО РМАНПО Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>17</day><month>02</month><year>2025</year></pub-date><volume>22</volume><issue>7</issue><issue-title>ПЕДИАТРИЯ</issue-title><fpage>7</fpage><lpage>12</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бережная И.В., Захарова И.Н., Османов И.М., Скоробогатова Е.В., Гончарова Л.В., Дмитриева Д.К., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Бережная И.В., Захарова И.Н., Османов И.М., Скоробогатова Е.В., Гончарова Л.В., Дмитриева Д.К.</copyright-holder><copyright-holder xml:lang="en">Berezhnaya I.V., Zakharova I.N., Osmanov I.M., Skorobogatova E.V., Goncharova L.V., Dmitrieva D.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://docru.elpub.ru/jour/article/view/143">https://docru.elpub.ru/jour/article/view/143</self-uri><abstract><sec><title>Цель обзора</title><p>Цель обзора. Проанализировать современные данные по эпидемиологии, патофизиологии развития эозинофильных гастроинтестинальных заболеваний (ЭГИЗ) у детей с акцентом на поражении тонкой кишки.</p></sec><sec><title>Основные положения</title><p>Основные положения. ЭГИЗ — это воспалительные состояния желудочно-кишечного тракта, характеризующиеся тканевой эозинофилией с глубиной повреждения органа от слизистой оболочки до мышечного и серозного слоя, что приводит к грубым нарушениям их структуры и функции. Значимость пищевой аллергии до настоящего момента остается недооцененной, хотя ею страдают около 5% детей и до 3–4% взрослых. Эозинофильные заболевания пищеварительного тракта привлекают пристальное внимание экспертов во всем мире. Несколько десятилетий назад данные болезни описывали как редкие, и в статьях были представлены единичные клинические наблюдения, а в настоящее время количество публикаций выросло на несколько порядков. Появляется все больше доказательств роли аэроаллергенов и пищевых аллергенов в патогенезе эозинофильных эзофагита, гастрита, энтерита, поскольку у детей и взрослых с ЭГИЗ часто выявляются положительные кожные тесты на пищевые аллергены и/или семейный анамнез аллергических заболеваний.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To analyze current data on epidemiology, pathophysiology of eosinophilic gastrointestinal diseases (EGID) in children with focus on small intestinal affection.</p></sec><sec><title>Key points</title><p>Key points. EGID are inflammatory conditions of the gastrointestinal tract, characterized by tissue eosinophilia with a depth of organ damage from the mucous layer to the muscular and serous layer, resulting in severe damage to their structure and function. Importance of food allergy is still underestimated, although it affects about 5% of children and up to 3–4% of adults. Eosinophilic diseases of the digestive tract are receiving close attention from experts all over the world. A few decades ago, these diseases were described as rare and articles presented isolated clinical cases, but nowadays the publications have increased by several times. There is increasing evidence of the role of aeroallergens and food allergens in the pathogenesis of eosinophilic esophagitis, gastritis, and enteritis, as children and adults with EGID are often found to have positive skin tests for food allergens and/or a family history of allergic diseases.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>эозинофильные поражения желудочно-кишечного тракта</kwd><kwd>эозинофильные гастроинтестинальные заболевания</kwd><kwd>эозинофильный эзофагит</kwd><kwd>эозинофильный гастрит</kwd><kwd>эозинофильный энтерит</kwd><kwd>пищевая аллергия</kwd><kwd>атопия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>eosinophilic disorders of the gastrointestinal tract</kwd><kwd>eosinophilic gastrointestinal diseases</kwd><kwd>eosinophilic esophagitis</kwd><kwd>eosinophilic  gastritis</kwd><kwd>eosinophilic enteritis</kwd><kwd>food allergy</kwd><kwd>atopy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Sicherer S.H., Sampson H.A. 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