docruДоктор.РуTitle1727-23782713-2994ООО "ГК "РУСМЕДИКАЛ"10.31550/1727-2378-2022-21-8-72-77docru-128Research ArticleПСИХИАТРИЯPSYCHIATRYРазличия модуляции ответов мозга на эмоциональные стимулы у мужчин и женщин при биполярной депрессииDifferences in Modulation of Brain Responses to Emotional Stimuli in Men and Women with Bipolar Depressionhttps://orcid.org/0000-0003-3407-1977МнацаканянЕ. В.MnatsakanianE. V.

Мнацаканян Елена Владимировна — к. б. н., старший научный сотрудник лаборатории высшей нервной деятельности человека

117485, г. Москва, ул. Бутлерова, д. 5а

5a Butlerov Str., Moscow, 117485

koala2006@mail.ruКрюковВ. В.KryukovV. V.

Крюков Вадим Викторович — к. м. н., ведущий научный сотрудник отделения расстройств аффективного спектра

107076, г. Москва, ул. Потешная, д. 3, стр. 10

3 Poteshnaya Str., build. 10, Moscow, 107076

vkrjukov@yandex.ruЖарковаА. С.ZharkovaA. S.

Жаркова Анастасия Сергеевна — младший научный сотрудник отделения расстройств аффективного спектра

107076, г. Москва, ул. Потешная, д. 3, стр. 10

3 Poteshnaya Str., build. 10, Moscow, 107076

psydocanazhar@gmail.comhttps://orcid.org/0000-0002-5249-3316КрасновВ. Н.KrasnovV. N.

Краснов Валерий Николаевич — д. м. н., профессор, руководитель отдела клинико-патогенетических исследований в психиатрии МНИИП — филиала ФГБУ «НМИЦ психиатрии и наркологии им. В.П. Сербского» Минздрава России; заведующий кафедрой психиатрии ФДПО ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России

107076, г. Москва, ул. Потешная, д. 3, стр. 10

3 Poteshnaya Str., build. 10, Moscow, 107076

valery-krasnov@mail.ruФГБУН «Институт высшей нервной деятельности и нейрофизиологии» РАНРоссияInstitute of Higher Nervous Activity and Neurophysiology (a Federal Government-funded Scientific Institution) Russian Academy of SciencesRussian FederationМосковский научно-исследовательский институт психиатрии — филиал ФГБУ «Национальный медицинский исследовательский центр психиатрии и наркологии имени В.П. Сербского» Министерства здравоохранения Российской ФедерацииРоссияMoscow Psychiatric Research Institute, a branch of the V.P. Serbsky National Medical Research Center for psychiatry and Narcology (a Federal Government-funded Institution) Russian Federation Ministry of HealthRussian FederationМосковский научно-исследовательский институт психиатрии — филиал ФГБУ «Национальный медицинский исследовательский центр психиатрии и наркологии имени В.П. Сербского» Министерства здравоохранения Российской Федерации; ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Министерства здравоохранения Российской ФедерацииРоссияMoscow Psychiatric Research Institute, a branch of the V.P. Serbsky National Medical Research Center for psychiatry and Narcology (a Federal Government-funded Institution) Russian Federation Ministry of Health; Pirogov Russian National Research Medical UniversityRussian Federation202217022025218НЕВРОЛОГИЯ. ПСИХИАТРИЯ7277Copyright © Мнацаканян Е.В., Крюков В.В., Жаркова А.С., Краснов В.Н., 20252025Мнацаканян Е.В., Крюков В.В., Жаркова А.С., Краснов В.Н.Mnatsakanian E.V., Kryukov V.V., Zharkova A.S., Krasnov V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://docru.elpub.ru/jour/article/view/128Цель исследования

Цель исследования: изучение прогностически и терапевтически значимых различий нейрофизиологической реактивности при биполярных депрессиях у мужчин и женщин.

Дизайн

Дизайн: cравнительное контролируемое нерандомизированное клинико-экспериментальное исследование.

Материалы и методы

Материалы и методы. Обследованы 53 пациента (26 мужчин и 27 женщин) с биполярной депрессией до начала психофармакотерапии. Возраст пациентов — от 21 года до 59 лет. Показатели по шкалам депрессии и тревоги Гамильтона у мужчин и женщин значимо не различались. В группы здоровых добровольцев вошли 23 мужчины и 29 женщин соответствующего возраста. Испытуемые сортировали фотографии, на 80 из которых представлены изображения злых/агрессивных людей или животных и на 80 — с нейтральным выражением. Простые фигуры (ключи) подавались за 2 с до картинок, их связь с фотографиями не объяснялась. Выполняли запись 128-канальной электроэнцефалограммы и анализ вызванных ключом ответов мозга. Различия (p < 0,05) между нейтральными и эмоциональными условиями определялись как эмоциональная модуляция (ЭМ).

Результаты

Результаты. Различия ЭМ у пациентов мужского и женского пола оказались более выраженными, чем в контрольных группах. У женщин с биполярной депрессией ЭМ стабильно локализовалась в задних областях коры от 100 мс и до конца эпохи анализа. У них отсутствовала ЭМ для компонента P100, а топография ЭМ для Р200 была ближе к норме, чем у мужчин. ЭМ компонентов N170 и P380 у пациентов различалась в зависимости от пола и отличалась от таковой у здоровых людей того же пола.

Заключение

Заключение. ЭМ активности мозга пациентов с биполярной депрессией отличается от ЭМ у здоровых людей. Отличия зависят от пола пациента и затрагивают несколько компонентов вызванной активности мозга. Это предполагает, что при исследованиях аффективных расстройств важно учитывать пол больных.

Study Objective

Study Objective: To investigate the prognostic and therapeutically significant characteristics in neurophysiological reactivity of male and female patients with bipolar depression.

Study Design

Study Design: comparative controlled non-randomized clinical experimental study.

Materials and Methods

Materials and Methods. 53 patients (26 men and 27 women) with bipolar depression were examined before the start of their psychopharmacotherapy. They were aged from 21 to 59 years. There were no significant differences between men and women on the Hamilton Depression and Anxiety Scale. The groups of healthy volunteers included 23 men and 29 women of the corresponding age. The participants sorted the photos, 80 of which were images of angry/aggressive people or animals, and 80 had neutral expressions. Simple figures (keys) were displayed 2 seconds before the pictures, their connection with the photographs was not explained. A 128-channel electroencephalogram was recorded and the brain responses elicited by the keys were analyzed. Differences (p < 0.05) between neutral and emotional conditions were defined as emotional modulation (EM).

Study Results

Study Results. EM differences in male and female patients were more pronounced than in the control groups. In women with bipolar depression, EM was consistently located in the posterior areas of the cortex from 100 ms to the end of the analysis period. The EM for the P100 component was missing, and the EM topography for P200 was closer to normal than in men. The EM of components N170 and P380 in patients differed depending on their sex and differed from EM of healthy controls of the same sex.

Conclusions

Conclusions. The EM of the brain activity in patients with bipolar depression differs from the EM of healthy people. The differences depend on the gender of the patient and affect several components of the evoked brain activity. This suggests that it is important to take into account the gender of the subjects when studying affective disorders in patients.

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The authors declare that there are no conflicts of interest present.